Disposition of Suprofen enantiomers in the cat

被引：5

作者：

Castro, EF ^{[1
]}

Soraci, AL ^{[1
]}

Franci, R ^{[1
]}

Fogel, FA ^{[1
]}

Tapia, MO ^{[1
]}

机构：

[1] Univ Nacl Ctr Prov Buenos Aires, Fac Ciencias Vet, Dept Fisopatol, Area Toxicol, RA-7000 Tandil, Buenos Aires, Argentina

来源：

VETERINARY JOURNAL | 2001年 / 162卷 / 01期

关键词：

Suprofen; cats; enantioselective; chiral inversion; glucuronidation;

D O I：

10.1053/tvjl.2001.0584

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Suprofen (SPF) is a non-steroidal anti-inflammatory drug (NSAID), which belongs to the 2-arylpropionic acids subclass.. As a result of their chiral characteristics, these compounds have shown a marked enantioselective behaviour with a high degree of interspecies variation. They are mainly eliminated by glucuronidation. Plasma, biliary and urine disposition of SPF was investigated in the cat after intravenous administration of the racemate (dose 2 mg/kg). Both enantiomers exhibited similar disposition profiles in plasma with no evidence of chiral inversion. During bile sampling time, recovered acylglucuronides of R (-) and S (+) SPF were less than 1% of the total dose administered. Only free SPF was recovered in the urine, representing 0.12% of the administered racemic SPF dose. The results indicate that neither chiral inversion nor glucuronidation predominate in SPF disposition in cats. (C) 2001 Harcourt Publishers Ltd.

引用

页码：38 / 43

页数：6

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[2]

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