Serum 25-Hydroxyvitamin D and the risk of breast cancer in women from Southern Morocco: A case-control study

OBJECTIVES: Assessing Vitamin-D status and checking if low serum 25(OH)D is a factor in breast cancer (BC) for Southern Moroccan women. MATERIALS/METHODS: Study conducted in Morocco about women with BC (n = 90) and controls (n = 90). 25-hydroxyvitamin-D biological analyzes executed during the first consultation. Social data and anthropometric parameters were collected for all participants. RESULTS: Women from urban areas constituted 67.78 % for the cases and 85.6% for the controls. The average age was 48.72 +/- 9.71 (cases) and 46.40 +/- 12.52 (controls). We found that 53.33% of cases and 40% of controls were postmenopausal and that hypovitaminosis-D affected 80 and 64.4% of cases and controls, respectively. Statistical analysis showed that hypovitaminosis-Dwas a significative risk factor for BC in Southern Moroccanwomen. The Odds Ratiowas of 5 (p < 0.0001). The BC subtypes had Odds Ratios greater than 1. The highest value was obtained with Luminal B subtype (Odds ratio = 6.25; p = 0.0007). CONCLUSION: This study reinforces the evidence implicating hypovitaminosis-D among modifiable risk factors for BC. Further studies are needed to assess the extent of hypovitaminosis-D in Moroccan women with BC.