Serum 25-Hydroxyvitamin D and the risk of breast cancer in women from Southern Morocco: A case-control study

被引:1
作者
Moukal, Abdellah [1 ,2 ]
El Farouqi, Abdallah [3 ,4 ]
Aghrouch, Mohamed [5 ]
Chadli, Smail [6 ]
Zekhnini, Abderrahmane [7 ]
Izaabel, El Hassan [1 ]
机构
[1] Fac Sci, Lab Cell Biol & Mol Genet, Agadir, Morocco
[2] Hlth Universe, Agadir, Morocco
[3] Fac Med, Agadir, Morocco
[4] Univ Hosp Ctr, Agadir, Morocco
[5] Hassan II Reg Hosp, Med Biol Dept, Agadir, Morocco
[6] ISPITS, Higher Inst Nursing Profess & Hlth Tech, Agadir, Morocco
[7] Fac Sci, Lab Aquat Syst, Agadir, Morocco
关键词
25-HydroxyVitamin-D; breast; case-control study; Moroccan population; VITAMIN-D STATUS; TUMOR CHARACTERISTICS; D DEFICIENCY; FOOD-INTAKE;
D O I
10.3233/MNM-211564
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVES: Assessing Vitamin-D status and checking if low serum 25(OH)D is a factor in breast cancer (BC) for Southern Moroccan women. MATERIALS/METHODS: Study conducted in Morocco about women with BC (n = 90) and controls (n = 90). 25-hydroxyvitamin-D biological analyzes executed during the first consultation. Social data and anthropometric parameters were collected for all participants. RESULTS: Women from urban areas constituted 67.78 % for the cases and 85.6% for the controls. The average age was 48.72 +/- 9.71 (cases) and 46.40 +/- 12.52 (controls). We found that 53.33% of cases and 40% of controls were postmenopausal and that hypovitaminosis-D affected 80 and 64.4% of cases and controls, respectively. Statistical analysis showed that hypovitaminosis-Dwas a significative risk factor for BC in Southern Moroccanwomen. The Odds Ratiowas of 5 (p < 0.0001). The BC subtypes had Odds Ratios greater than 1. The highest value was obtained with Luminal B subtype (Odds ratio = 6.25; p = 0.0007). CONCLUSION: This study reinforces the evidence implicating hypovitaminosis-D among modifiable risk factors for BC. Further studies are needed to assess the extent of hypovitaminosis-D in Moroccan women with BC.
引用
收藏
页码:361 / 368
页数:8
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