Synthesis of Functional Core, Star Polymers via RAFT Polymerization for Drug Delivery Applications

被引：137

作者：

Liu, Jinna ^{[1
]}

Duong, Hien ^{[1
]}

Whittaker, Michael R. ^{[1
]}

Davis, Thomas P. ^{[1
]}

Boyer, Cyrille ^{[1
]}

机构：

[1] Univ New S Wales, Australian Ctr Nanomed, Sch Chem Engn, Sydney, NSW 2052, Australia

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2012年 / 33卷 / 09期

基金：

澳大利亚研究理事会;

关键词：

click-chemistry; drug delivery systems; responsive polymers; star polymers; well-defined nanoparticles; TRANSFER RADICAL POLYMERIZATION; POLY(ETHYLENE OXIDE); WATER; ARCHITECTURES; RHEOLOGY; DESIGN; BLOCK; DEGRADATION; COMBINATION; DOXORUBICIN;

D O I：

10.1002/marc.201200029

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(oligoethylene glycol) methyl ether acrylate was polymerized via reversible addition fragmentation transfer polymerization (RAFT), and then chain extended in the presence of both a cross-linker and vinyl benzaldehyde (VBA), yielding monodisperse star polymers. The presence of aldehyde groups in the core was exploited to attach doxorubicin. The drug loading was controlled by the amount of VBA incorporated (until 28 wt% in drug). The doxorubicin release was studied at pH = 5.5 and 7.4; conditions representative of endosomal and extra cellular environments. In vitro studies revealed that the doxorubicin-conjugated star polymers had a level of cytotoxicity comparable to that found for free doxorubicin. Confocal microscopy and flow cytometry studies confirmed efficient cell uptake of the star polymers.

引用

页码：760 / 766

页数：7

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