Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides

被引：14
|
作者：
Fan, Tao [1 ]
Meng, Wei-Dong [1 ]
Zhang, Xingang [2 ]
机构：
[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, 2999 North Renmin Rd, Shanghai 201620, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 13卷
基金：
中国国家自然科学基金;
关键词：
alkenes; cross-coupling; Heck-type reaction; palladium; secondary trifluoromethylated alkyl bromides; COPPER-MEDIATED DIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; HALIDES; IODIDES; ALKENES; FLUORINATION; MOIETY;
D O I：
10.3762/bjoc.13.258
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction.
引用
收藏
页码：2610 / 2616
页数：7
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