Induction of type I interferon by high-molecular poly-γ-glutamate protects B6.A2G-Mx1 mice against influenza A virus

被引：19
作者：
Moon, Ho-Jin
Lee, Jong-Soo
Choi, Young-Ki [2 ,3 ]
Park, Jie-Yeun [4 ]
Talactac, Melbourne R.
Chowdhury, Mohammed Y. E.
Poo, Haryoung [5 ]
Sung, Moon-Hee [6 ,7 ]
Lee, Ji-Hoon [8 ]
Jung, Jae U. [9 ]
Kim, Chul-Joong [1 ]
机构：
[1] Chungnam Natl Univ, Infect Dis Lab, Coll Vet Med, Taejon 305764, South Korea
[2] Chungbuk Natl Univ, Coll Med, Cheongju, South Korea
[3] Chungbuk Natl Univ, Med Res Inst, Cheongju, South Korea
[4] Chungnam Natl Univ, Coll Agr & Life Sci, Taejon 305764, South Korea
[5] Korea Res Inst Biosci & Biotechnol, Viral Infect Dis Res Ctr, Taejon, South Korea
[6] Kookmin Univ, Dept Adv Fermentat Fus Sci & Technol, Seoul, South Korea
[7] BioLeaders Corp, Taejon, South Korea
[8] Dongbang Corp, Seoul, South Korea
[9] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
来源：
ANTIVIRAL RESEARCH | 2012年 / 94卷 / 01期
关键词：
High-molecular-weight poly-gamma-glutamate; Myxovirus resistance protein; Interferon type I; B6.A2G-Mx1; mouse; Influenza A virus; ACID;
D O I：
10.1016/j.antiviral.2012.02.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In addition to development of vaccines and synthetic antiviral drugs, recent studies have advocated the use of natural substances that inhibit or prevent viral infections. High-molecular-weight poly-gamma-glutamate (HM-gamma-PGA) produced by Bacillus subtilis chungkookjang was evaluated for anti-influenza virus activity. HM-gamma-PGA induced type I interferons (IFNs), which in turn stimulated expression of Myxovirus resistant 1 protein and IFN-related proteins in vitro. In the B6.A2G-Mx1 mouse model, which mimics the innate immune system of humans, treatment with HM-gamma-PGA enhanced the antiviral state of mice and protected them against highly pathogenic influenza A virus. Naturally synthesized HM-gamma-PGA has potent anti-influenza activity and may be a useful means for control of influenza virus. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：98 / 102
页数：5
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