Assembly of N,N-Disubstituted Hydrazines and 1-Aryl-1H-indazoles via Copper-Catalyzed Coupling Reactions

被引：118

作者：

Xiong, Xiaodong

Jiang, Yongwen

Ma, Dawei ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 10期

基金：

中国国家自然科学基金;

关键词：

UNSYMMETRICAL AZO-COMPOUNDS; FISCHER INDOLE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; INTRAMOLECULAR AMINATION; ARYL IODIDES; N-ARYLATION; DERIVATIVES; EFFICIENT; ANTAGONISTS; INHIBITORS;

D O I：

10.1021/ol300847v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cul-catalyzed coupling of N-acyl-N-substituted hydrazines with aryl iodides takes place at 60-90 degrees C to afford N-acyl-N,N-disubstituted hydrazines regioselectively and thereby gives a facile method for assembling N,N-diaryl hydrazines. N-Acyl-N-substituted hydrazines can also react with 2-bromoarylcaibonylic compounds at 60-125 degrees C under the catalysis of Cul/4-hydroxy-L-proline to provide 1-aryl-1H-indazoles.

引用

收藏

页码：2552 / 2555

页数：4

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