Assembly of N,N-Disubstituted Hydrazines and 1-Aryl-1H-indazoles via Copper-Catalyzed Coupling Reactions

被引：116
|
作者：
Xiong, Xiaodong
Jiang, Yongwen
Ma, Dawei [1 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 10期
基金：
中国国家自然科学基金;
关键词：
UNSYMMETRICAL AZO-COMPOUNDS; FISCHER INDOLE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; INTRAMOLECULAR AMINATION; ARYL IODIDES; N-ARYLATION; DERIVATIVES; EFFICIENT; ANTAGONISTS; INHIBITORS;
D O I：
10.1021/ol300847v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cul-catalyzed coupling of N-acyl-N-substituted hydrazines with aryl iodides takes place at 60-90 degrees C to afford N-acyl-N,N-disubstituted hydrazines regioselectively and thereby gives a facile method for assembling N,N-diaryl hydrazines. N-Acyl-N-substituted hydrazines can also react with 2-bromoarylcaibonylic compounds at 60-125 degrees C under the catalysis of Cul/4-hydroxy-L-proline to provide 1-aryl-1H-indazoles.
引用
收藏
页码：2552 / 2555
页数：4
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