Chordomas: A Review

被引：74

作者：

George, Bernard ^{[1
]}

Bresson, Damien ^{[1
]}

Herman, Philippe ^{[2
]}

Froelich, Sebastien ^{[1
]}

机构：

[1] Univ Paris Diderot, Dept Neurosurg, Hop Lariboisiere, AP HP, F-75475 Paris, France

[2] Univ Paris Diderot, ENT Dept, Hop Lariboisiere, AP HP, F-75475 Paris, France

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2015年 / 26卷 / 03期

关键词：

Chordomas; Endonasal approach; Proton beam therapy; DEDIFFERENTIATED CHORDOMA; ECCHORDOSIS-PHYSALIPHORA; INTRACRANIAL CHORDOMA; CERVICAL CHORDOMAS; FAMILIAL CHORDOMA; MOBILE SPINE; CELL-TUMORS; SKULL BASE; MANAGEMENT; BRACHYURY;

D O I：

10.1016/j.nec.2015.03.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chordomas (CHs) are tumors with benign histopathology but exhibit aggressive clinical behavior with invasive and metastatic potential. CHs are challenging tumors to treat, and there are still many questions, especially about their optimum treatment. Radical resection at first presentation should be applied on all CHs. Complementary proton therapy irrespective of the quality of resection is now routinely proposed even if its efficacy is not clearly demonstrated in case of incomplete resection. The future of CH treatment is certainly related to a better understanding of the molecular biology and oncogenesis of CHs and consequently to the development of efficient targeted chemotherapies.

引用

页码：437 / +

页数：17

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