Nickel-catalyzed multiple component domino couplings

Intramolecular domino transformations are useful for synthesizing complex compounds. On the other hand, the development of synthetically useful intermolecular multiple component domino reactions is in its infancy. The nickel-catalyzed reactions summarized in this account are among the practical intermolecular domino couplings that have been developed to date and should find wide application in organic synthesis. For instance, a variety of starting materials such as alkenes, alkynes, and unsaturated carbonyl compounds can be connected with high selectivity under reasonably mild conditions. Furthermore, an asymmetric version of the reaction is also successful.