First iron-catalyzed guanylation of amines: a simple and highly efficient protocol to guanidines

被引：34

作者：

Pottabathula, Srinivas ^{[1
]}

Royo, Beatriz ^{[1
]}

机构：

[1] Univ Nova Lisboa, Inst Tecnol Quim & Biol, EAN, P-2780157 Oeiras, Portugal

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 38期

关键词：

Iron catalyzed; Guanylation; Homogeneous catalysis; Amines; Guanidines; EARTH-METAL COMPLEXES; SUBSTITUTED GUANIDINES; ORGANIC-SYNTHESIS; SECONDARY-AMINES; N-H; CARBODIIMIDES; CONSTRUCTION; LANTHANIDE; ACTIVATION; YTTRIUM;

D O I：

10.1016/j.tetlet.2012.07.065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first iron-catalyzed guanylation of amines is reported. Commercially available Fe(OAc)(2) acts as an excellent catalyst for the addition of amines to carbodiimides. The reaction is broadly applicable to a variety of primary, secondary, and heterocyclic amines, and tolerates a wide range of functionalities allowing the easy preparation of a large family of guanidines. The low price and low toxicity of the commercially available iron catalyst make this methodology highly attractive. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5156 / 5158

页数：3

共 31 条

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