Role of serotonin (5-HT)1B receptors in psychostimulant addiction

被引：0

作者：

Miszkiel, Joanna ^{[1
]}

Filip, Malgorzata ^{[1
]}

Przegalinski, Edmund ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Pharmacol, Dept Pharmacol, Lab Drug Addict Pharmacol, PL-31343 Krakow, Poland

来源：

PHARMACOLOGICAL REPORTS | 2011年 / 63卷 / 06期

关键词：

5-HTIB receptors; psychostimulants; behavioral models of drug addiction; VENTRAL TEGMENTAL AREA; COCAINE-SEEKING BEHAVIOR; 5-HT1B MESSENGER-RNA; NUCLEUS-ACCUMBENS; RAT-BRAIN; EXTRACELLULAR DOPAMINE; BINDING-SITES; D-AMPHETAMINE; RU; 24969; LIGANDS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Psychostimulant (cocaine, amphetamine and its derivatives) addiction is an important health problem with implications in social and economic life. Although mesocorticolimbic dopamine system plays a crucial role in the mechanism responsible for the rewarding effects of these drugs, recent data also show involvement of the brain serotonin (5-HT) system. In the present review we discuss the role of 5-HTIB receptors in the psychostimulant addiction on the base of the effects of 5-HTIB receptor ligands on the behavioral effects of the psychostimulants in experimental models (sensitization, intracranial self-stimulation, conditioned place preference, self-administration and extinction/reinstatement model) used to assess their addictive properties. Moreover, the effect of long-term treatment with psychostimulants on 5-HTIB receptors is also discussed.

引用

页码：1310 / 1315

页数：6

共 50 条

[11] Inverse agonist properties of antipsychotic agents at cloned, human (h) serotonin (5-HT)1B and h5-HT1D receptors
Audinot, V
Newman-Tancredi, A
Cussac, D
Millan, MJ
NEUROPSYCHOPHARMACOLOGY, 2001, 25 (03) : 410 - 422
[12] REGULATION OF SEROTONIN (5-HT) RELEASE IN SPINAL-CORD BY 5-HT1B RECEPTORS
JONES, D
COMBS, MR
FEDERATION PROCEEDINGS, 1987, 46 (03) : 965 - 965
[13] Cloning and characterization of chicken 5-hydroxytryptamine (5-HT) receptors 1A and 1B
Wong, C. F.
Kwok, A. H. Y.
Ho, J. C. W.
Wang, Y.
Leung, F. C.
JOURNAL OF DAIRY SCIENCE, 2010, 93 : 679 - 679
[14] SEROTONERGIC MODULATION OF NEUROTRANSMISSION IN THE RAT SUBICULAR CORTEX IN-VITRO - A ROLE FOR 5-HT(1B) RECEPTORS
BOEIJINGA, PH
BODDEKE, HWGM
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1993, 348 (06) : 553 - 557
[15] Polymorphism of Serotonin 5-HT Receptors as the Basis of the Multifunctionality of Serotonin
N. K. Popova
V. S. Naumenko
Neuroscience and Behavioral Physiology, 2012, 42 (2) : 161 - 166
[16] Regulation by serotonin (5-HT)-1A receptors of 5-HT and dopamine release in mouse prefrontal cortex
Matsuda, T
Ago, Y
Baba, A
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2004, 7 : S295 - S295
[17] SEROTONIN STIMULATES DNA-SYNTHESIS IN FIBROBLASTS ACTING THROUGH 5-HT 1B RECEPTORS COUPLED TO A GI-PROTEIN
SEUWEN, K
MAGNALDO, I
POUYSSEGUR, J
NATURE, 1988, 335 (6187) : 254 - 256
[18] ACTIVATION OF 5-HT RECEPTORS LOCATED IN THE FOREBRAIN CAUSES SYMPATHOEXCITATION IN ANESTHETIZED CATS - A ROLE FOR 5-HT(2)-RECEPTORS AND OR 5-HT(1C)-RECEPTORS
ANDERSON, IK
MARTIN, GR
RAMAGE, AG
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 : P107 - P107
[19] Effects of serotonin (5-HT)1B receptor ligands on amphetamine-seeking behavior in rats
Miszkiel, Joanna
Przegalinski, Edmund
PHARMACOLOGICAL REPORTS, 2013, 65 (04) : 813 - 822
[20] The role of central 5-hydroxytryptamine (5-HT, serotonin) receptors in the control of micturition
Ramage, AG
BRITISH JOURNAL OF PHARMACOLOGY, 2006, 147 : S120 - S131

← 1 2 3 4 5 →