Clinical Relevance of C4d Deposition in Pediatric Immunoglobulin A Nephropathy

被引：12

作者：

Baek, Hee Sun ^{[1
]}

Han, Man Hoon ^{[2
]}

Kim, Yong Jin ^{[2
]}

Cho, Min Hyun ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu 41944, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2018年 / 37卷 / 05期

关键词：

IgA nephropathy; C4d; mesangial proliferation; proteinuria; children; IGA NEPHROPATHY; OXFORD CLASSIFICATION; COMPLEMENT; ACTIVATION; ASSOCIATION; PROGRESSION; REJECTION;

D O I：

10.1080/15513815.2018.1504841

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Introduction: Few studies have reported the association between the complement cascade and pediatric immunoglobulin A nephropathy (IgAN). This study aimed to investigate the association between C4d staining positivity and the clinical/histopathological characteristics of pediatric patients with IgAN. Methods: Children diagnosed with IgAN through renal biopsy were retrospectively reviewed. Renal biopsy specimens were stained using C4d immunohistochemistry. Results: Among the 56 patients, 31 (55.4%) showed positive mesangial or peripheral capillary C4d staining in glomeruli. Urine protein-to-creatinine ratio was significantly higher in C4d-positive patients (p = 0.001). The severity of mesangial proliferation according to the Haas and Oxford classification was positively associated with positive C4d staining (p < 0.001). Conclusion: Positive C4d staining was found to be significantly associated with the clinical/histopathological severity of IgAN.

引用

页码：326 / 336

页数：11

共 25 条

[1] Predicting progression in IgA nephropathy [J].

Bartosik, LP ;

Lajoie, G ;

Sugar, L ;

Cattran, DC .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2001, 38 (04) :728-735

[2] IMMUNOGLOBULIN-A - INTERACTION WITH COMPLEMENT, PHAGOCYTIC-CELLS AND ENDOTHELIAL-CELLS [J].

BOGERS, WMJM ;

STAD, RK ;

VANES, LA ;

DAHA, MR .

COMPLEMENT AND INFLAMMATION, 1991, 8 (5-6) :347-358

[3] The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification [J].

Cattran, Daniel C. ;

Coppo, Rosanna ;

Cook, H. Terence ;

Feehally, John ;

Roberts, Ian S. D. ;

Troyanov, Stephan ;

Alpers, Charles E. ;

Amore, Alessandro ;

Barratt, Jonathan ;

Berthoux, Francois ;

Bonsib, Stephen ;

Bruijn, Jan A. ;

D'Agati, Vivette ;

D'Amico, Giuseppe ;

Emancipator, Steven ;

Emma, Francesco ;

Ferrario, Franco ;

Fervenza, Fernando C. ;

Florquin, Sandrine ;

Fogo, Agnes ;

Geddes, Colin C. ;

Groene, Hermann-Josef ;

Haas, Mark ;

Herzenberg, Andrew M. ;

Hill, Prue A. ;

Hogg, Ronald J. ;

Hsu, Stephen I. ;

Jennette, J. Charles ;

Joh, Kensuke ;

Julian, Bruce A. ;

Kawamura, Tetsuya ;

Lai, Fernand M. ;

Leung, Chi Bon ;

Li, Lei-Shi ;

Li, Philip K. T. ;

Liu, Zhi-Hong ;

Mackinnon, Bruce ;

Mezzano, Sergio ;

Schena, F. Paolo ;

Tomino, Yasuhiko ;

Walker, Patrick D. ;

Wang, Haiyan ;

Weening, Jan J. ;

Yoshikawa, Nori ;

Zhang, Hong .

KIDNEY INTERNATIONAL, 2009, 76 (05) :534-545

[4] Antibody-mediated renal allograft rejection: Diagnosis and pathogenesis [J].

Colvin, Robert B. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (04) :1046-1056

[5] The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults [J].

Coppo, Rosanna ;

Troyanov, Stephan ;

Camilla, Roberta ;

Hogg, Ronald J. ;

Cattran, Daniel C. ;

Cook, H. Terence ;

Feehally, John ;

Roberts, Ian S. D. ;

Amore, Alessandro ;

Alpers, Charles E. ;

Barratt, Jonathan ;

Berthoux, Francois ;

Bonsib, Stephen ;

Bruijn, Jan A. ;

D'Agati, Vivette ;

D'Amico, Giuseppe ;

Emancipator, Steven N. ;

Emma, Francesco ;

Ferrario, Franco ;

Fervenza, Fernando C. ;

Florquin, Sandrine ;

Fogo, Agnes B. ;

Geddes, Colin C. ;

Groene, Hermann J. ;

Haas, Mark ;

Herzenberg, Andrew M. ;

Hill, Prue A. ;

Hsu, Stephen I. ;

Jennette, J. Charles ;

Joh, Kensuke ;

Julian, Bruce A. ;

Kawamura, Tetsuya ;

Lai, Fernand M. ;

Li, Lei S. ;

Li, Philip K. ;

Liu, Zhi H. ;

Mezzano, Sergio ;

Schena, F. Paolo ;

Tomino, Yasuhiko ;

Walker, Patrick D. ;

Wang, Haiyan ;

Weening, Jan J. ;

Yoshikawa, Norishige ;

Zhang, Hong .

KIDNEY INTERNATIONAL, 2010, 77 (10) :921-927

[6]

DAMICO G, 1986, Q J MED, V59, P363

[7] Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy [J].

Endo, M ;

Ohi, H ;

Ohsawa, I ;

Fujita, T ;

Matsushita, M ;

Fujita, T .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1998, 13 (08) :1984-1990

[8] Association of C4d Deposition with Clinical Outcomes in IgA Nephropathy [J].

Espinosa, Mario ;

Ortega, Rosa ;

Sanchez, Marina ;

Segarra, Alfons ;

Teresa Salcedo, Maria ;

Gonzalez, Fayna ;

Camacho, Rafael ;

Angel Valdivia, Miguel ;

Cabrera, Rocio ;

Lopez, Katia ;

Pinedo, Fernando ;

Gutierrez, Eduardo ;

Valera, Alfonso ;

Leon, Miryam ;

Angeles Cobo, Maria ;

Rodriguez, Rosa ;

Ballarin, Jose ;

Arce, Yolanda ;

Garcia, Beatriz ;

Dolores Munoz, Maria ;

Praga, Manuel .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 9 (05) :897-904

[9] Mesangial C4d deposition: a new prognostic factor in IgA nephropathy [J].

Espinosa, Mario ;

Ortega, Rosa ;

Gomez-Carrasco, Jose Manuel ;

Lopez-Rubio, Fernando ;

Lopez-Andreu, Maria ;

Lopez-Oliva, Maria Ovidia ;

Aljama, Pedro .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (03) :886-891

[10] Combined C4d and CD3 immunostaining predicts immunoglobulin (Ig)A nephropathy progression [J].

Faria, B. ;

Henriques, C. ;

Matos, A. C. ;

Daha, M. R. ;

Pestana, M. ;

Seelen, M. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2015, 179 (02) :354-361

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