Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents

被引：26

作者：

Siberry, George K. ^{[1
]}

Leister, Erin ^{[2
]}

Jacobson, Denise L. ^{[2
]}

Foster, Samuel B. ^{[3
]}

Seage, George R., III ^{[2
,4
]}

Lipshultz, Steven E. ^{[5
]}

Paul, Mary E. ^{[6
]}

Purswani, Murli ^{[7
]}

Colin, Andrew A. ^{[5
]}

Scott, Gwendolyn ^{[5
]}

Shearer, William T. ^{[6
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pediat Adolescent & Maternal AIDS Branch, NIH, Bethesda, MD USA

[2] Harvard Univ, Sch Publ Hlth, Dept Biostat, Ctr Biostat AIDS Res, Boston, MA 02115 USA

[3] SW Allergy & Asthma Ctr, Plano, TX USA

[4] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[5] Univ Miami, Miller Sch Med, Dept Pediat, Div Clin Res, Coral Gables, FL 33124 USA

[6] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[7] Albert Einstein Coll Med, Bronx Lebanon Hosp Ctr, Bronx, NY 10467 USA

来源：

CLINICAL IMMUNOLOGY | 2012年 / 142卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Atopic dermatitis; Asthma; Pediatric HIV infection; Inhaled corticosteroids; Protease inhibitors; HUMAN-IMMUNODEFICIENCY-VIRUS; CUSHING-SYNDROME; INFANTS; FLUTICASONE; ASSOCIATION; PREVALENCE; DISORDERS; RITONAVIR; THERAPY; AIRWAY;

D O I：

10.1016/j.clim.2011.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The incidence of asthma and atopic dermatitis (AD) was evaluated in HIV-infected (n=451) compared to HIV-exposed (n=227) but uninfected (HEU) children and adolescents by abstraction from clinical charts. Asthma was more common in HIV-infected compared to HEU children by clinical diagnosis (25% vs. 20%, p=0.101), by asthma medication use, (31% vs. 22%, p=0.012), and by clinical diagnosis and/or medication use, (34% vs. 25%, p = 0.012). HIV-infected children had a greater risk of asthma compared to HEU children (HR = 1.37, 95% CI: 1.01 to 1.86). AD was more common in HIV-infected than HEU children (20% vs. 12%, p=0.009)) and children with AD were more likely to have asthma in both cohorts (41% vs. 29%, p=0.010). HIV-infected children and adolescents in this study had an increased incidence of asthma and AD, a finding critical for millions of HIV-infected children worldwide. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：201 / 208

页数：8

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