Nanotechnology for angiogenesis: opportunities and challenges

被引：178

作者：

Kargozar, Saeid ^{[1
]}

Baino, Francesco ^{[2
]}

Hamzehlou, Sepideh ^{[3
,4
]}

Hamblin, Michael R. ^{[5
,6
,7
]}

Mozafari, Masoud ^{[8
,9
]}

机构：

[1] Mashhad Univ Med Sci, Sch Med, Dept Anat & Cell Biol, Tissue Engn Res Grp TERG, Mashhad 9177948564, Razavi Khorasan, Iran

[2] Politecn Torino, Inst Mat Phys & Engn, Appl Sci & Technol Dept, Corso Duca Abruzzi 24, I-10129 Turin, Italy

[3] Mashhad Univ Med Sci, Ghaem Hosp, Mol Pathol & Cytogenet Lab, Mashhad, Razavi Khorasan, Iran

[4] Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran

[5] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[6] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA

[7] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, ZA-2028 Doornfontein, South Africa

[8] Iran Univ Med Sci, Fac Adv Technol Med, Dept Tissue Engn & Regenerat Med, Tehran, Iran

[9] Univ Toronto, Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

来源：

CHEMICAL SOCIETY REVIEWS | 2020年 / 49卷 / 14期

关键词：

ENDOTHELIAL GROWTH-FACTOR; SOLID LIPID NANOPARTICLES; NF-KAPPA-B; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; MODIFIED GELATIN NANOPARTICLES; EPITHELIAL OVARIAN-CARCINOMA; MESOPOROUS BIOACTIVE GLASSES; IONIC DISSOLUTION PRODUCTS; CERIUM OXIDE NANOPARTICLES; CARBON-BASED NANOMATERIALS;

D O I：

10.1039/c8cs01021h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Angiogenesis plays a critical role within the human body, from the early stages of life (i.e., embryonic development) to life-threatening diseases (e.g., cancer, heart attack, stroke, wound healing). Many pharmaceutical companies have expended huge efforts on both stimulation and inhibition of angiogenesis. During the last decade, the nanotechnology revolution has made a great impact in medicine, and regulatory approvals are starting to be achieved for nanomedicines to treat a wide range of diseases. Angiogenesis therapies involve the inhibition of angiogenesis in oncology and ophthalmology, and stimulation of angiogenesis in wound healing and tissue engineering. This review aims to summarize nanotechnology-based strategies that have been explored in the broad area of angiogenesis. Lipid-based, carbon-based and polymeric nanoparticles, and a wide range of inorganic and metallic nanoparticles are covered in detail. Theranostic and imaging approaches can be facilitated by nanoparticles. Many preparations have been reported to have a bimodal effect where they stimulate angiogenesis at low dose and inhibit it at higher doses.

引用

页码：5008 / 5057

页数：50

共 588 条

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