N-(4-Chloro-2-nitrophenyl)-5-methylisoxazole-4-carboxamide

被引：0

作者：

Wang, De-Cai ^{[1
]}

Huang, Liang-Cheng ^{[1
]}

Liu, Zhu-Yun ^{[1
]}

Wei, Ping ^{[1
]}

Ou-yang, Ping-Kai ^{[1
]}

机构：

[1] Nanjing Univ Technol, Sch Pharmaceut Sci, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2011年 / 67卷

关键词：

LEFLUNOMIDE;

D O I：

10.1107/S1600536811047994

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the title compound, C11H8ClN3O4, the dihedral angle between benzene and isoxazole rings is 9.92 (1) degrees. The nitro group is almost coplanar with the benzene ring with an O-N-C-C torsion angle of 8.4 (3)degrees. The molecular conformation is stabilized by an intramolecular N-H center dot center dot center dot O hydrogen bond, closing a six-membered ring.

引用

页码：O3332 / U1411

页数：8

共 12 条

[1] Comparison of Two Molecular Scaffolds, 5-Methylisoxazole-3-Carboxamide and 5-Methylisoxazole-4-Carboxamide
Song, Yaoming
Zhang, Yiguan
Lee, An-Rong
Huang, Wen-Hsin
Chen, Ben
Palfey, Bruce
Shaw, Jiajiu
CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (01) : 146 - 152
[2] N-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide monohydrate
Wang, De-Cai
Huang, Liang-Cheng
Liu, Hua-Quan
Peng, Yu-Ran
Song, Jun-Song
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O3207 - U1719
[3] Studies on the Deamination of the Ethyl Ester of 5-Amino-3-methylisoxazole-4-carboxylic Acid
Ryng, S.
Szostak, M.
POLISH JOURNAL OF CHEMISTRY, 2009, 83 (05) : 887 - 893
[4] Immunoregulatory effects of 4-(4-chlorophenyl)-1-(5-amino-3-methylisoxazole-4-carbonyl)-thiosemicarbazide (06K) in non-immunized and SRBC-immunized mice
Drynda, Angelika
Obminska-Mrukowicz, Bozena
Zaczynska, Ewa
Zimecki, Michal
Ryng, Stanislaw
Maczynski, Marcin
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2016, 68 (12) : 1613 - 1620
[5] Normal coordinate analysis and vibrational spectroscopy (FT-IR and FT-Raman) studies of 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide using density functional method
Shahidha, R.
Muthu, S.
Porchelvi, E. Elamurugu
Govindarajan, M.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2014, 132 : 142 - 151
[6] Identification of 5-methylisoxazole-4-carboxylic acid and 4-(trifluoromethyl)aniline degradation products for leflunomide by high-performance thin-layer chromatography coupled with high-resolution mass spectrometry
M. R. Ghante
S. R. Sawant
V. K. Bhusari
S. D. Sawant
S. S. Jagtap
JPC – Journal of Planar Chromatography – Modern TLC, 2022, 35 : 635 - 641
[7] Identification of 5-methylisoxazole-4-carboxylic acid and 4-(trifluoromethyl)aniline degradation products for leflunomide by high-performance thin-layer chromatography coupled with high-resolution mass spectrometry
Ghante, M. R.
Sawant, S. R.
Bhusari, V. K.
Sawant, S. D.
Jagtap, S. S.
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 2022, 35 (06) : 635 - 641
[8] DEGRADATION OF THE ANTIARTHRITIC PRODRUG, 3-CARBOXY-5-METHYL-N-[4-(TRIFLUOROMETHOXY)PHENYL]-4-ISOXAZOLECARBOXAMIDE, IN AQUEOUS-SOLUTION
BRANDL, M
KENNEDY, JA
PHARMACEUTICAL RESEARCH, 1994, 11 (02) : 345 - 348
[9] Inhibition of Human DHODH by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)anthranilic Acids Identified by Structure-Guided Fragment Selection
Fritzson, Ingela
Svensson, Bo
Al-Karadaghi, Salam
Walse, Bjorn
Wellmar, Ulf
Nilsson, Ulf J.
Thrige, Dorthe da Graca
Jonsson, Stig
CHEMMEDCHEM, 2010, 5 (04) : 608 - 617
[10] Differential modulation of pro- and antiinflammatory cytokine receptors by N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxy-crotonic acid amide (A77 1726), the physiologically active metabolite of the novel immunomodulator leflunomide
Mirmohammadsadegh, A
Homey, B
Abts, HF
Köhrer, K
Ruzicka, T
Michel, G
BIOCHEMICAL PHARMACOLOGY, 1998, 55 (09) : 1523 - 1529

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