RIPK3: Beyond Necroptosis

被引：10

作者：

Evans, Azia S. ^{[1
,2
]}

Coyne, Carolyn B. ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA 15261 USA

[2] UPMC Childrens Hosp Pittsburgh, Ctr Microbial Pathogenesis, Pittsburgh, PA USA

[3] UPMC Childrens Hosp Pittsburgh, RK Mellon Inst Pediat Res, Pittsburgh, PA 15219 USA

来源：

IMMUNITY | 2019年 / 50卷 / 01期

关键词：

PATHOGENESIS;

D O I：

10.1016/j.immuni.2018.12.031

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.

引用

页码：1 / 3

页数：3

共 8 条

[1] Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels [J].

Cordes, Thekla ;

Wallace, Martina ;

Michelucci, Alessandro ;

Divakaruni, Ajit S. ;

Sapcariu, Sean C. ;

Sousa, Carole ;

Koseki, Haruhiko ;

Cabrales, Pedro ;

Murphy, Anne N. ;

Hiller, Karsten ;

Metallo, Christian M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (27) :14274-14284

[2] The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons [J].

Daniels, Brian P. ;

Kofman, Sigal B. ;

Smith, Julian R. ;

Norris, Geoffrey T. ;

Snyder, Annelise G. ;

Kolb, Joseph P. ;

Gao, Xia ;

Locasale, Jason W. ;

Martinez, Jennifer ;

Gale, Michael, Jr. ;

Loo, Yueh-Ming ;

Oberst, Andrew .

IMMUNITY, 2019, 50 (01) :64-+

[3] Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome [J].

Kang, Tae-Bong ;

Yang, Seung-Hoon ;

Toth, Beata ;

Kovalenko, Andrew ;

Wallach, David .

IMMUNITY, 2013, 38 (01) :27-40

[4] Protective and Pathological Immunity during Central Nervous System Infections [J].

Klein, Robyn S. ;

Hunter, Christopher A. .

IMMUNITY, 2017, 46 (06) :891-909

[5] Flaviviruses and the Central Nervous System: Revisiting Neuropathological Concepts [J].

Maximova, Olga A. ;

Pletnev, Alexander G. .

ANNUAL REVIEW OF VIROLOGY, VOL 5, 2018, 5 :255-272

[6] Zika Virus Pathogenesis and Tissue Tropism [J].

Miner, Jonathan J. ;

Diamond, Michael S. .

CELL HOST & MICROBE, 2017, 21 (02) :134-142

[7] Innate immune interactions within the central nervous system modulate pathogenesis of viral infections [J].

Nair, Sharmila ;

Diamond, Michael S. .

CURRENT OPINION IN IMMUNOLOGY, 2015, 36 :47-53

[8] Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases [J].

Yuan, Junying ;

Amin, Palak ;

Ofengeim, Dimitry .

NATURE REVIEWS NEUROSCIENCE, 2019, 20 (01) :19-33

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