The Cytotoxic Effect of Combined Hyperthermia and Taxane Chemotherapy on Ovarian Cancer Cells: Results of an in vitro Study

被引：6
作者：
Muller, M. [1 ,2 ]
Cherel, M. [2 ]
Dupre, P. -F. [1 ]
Gouard, S. [2 ]
Collet, M. [1 ]
Classe, J. -M. [2 ,3 ]
机构：
[1] Ctr Hosp Univ Augustin Morvan, Unit Gynecol & Mammary Oncol Surg, FR-29609 Brest, France
[2] Univ Nantes, Angers INSERM Unit 892, Ctr Canc Res, Nantes, France
[3] Ctr Rene Gauducheau, Dept Surg Oncol, St Herblain, France
来源：
EUROPEAN SURGICAL RESEARCH | 2012年 / 48卷 / 02期
关键词：
Hyperthermia; Chemotherapy; Taxanes; Ovarian cancer cells; THERMAL ENHANCEMENT; PACLITAXEL; TEMPERATURE; ADENOCARCINOMA; ANTIGEN; AGENTS; LINE;
D O I：
10.1159/000333393
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Purpose: Hyperthermic intraperitoneal chemotherapy (HIPEC) is under continuous evaluation as a potential treatment for ovarian cancer. The purpose of this study was to evaluate the effect of chemotherapy, drug concentration and temperature. Materials and Methods: We examined the combined effects of hyperthermia and taxane chemotherapy on the clonogenic survival of the human ovarian carcinoma SHIN-3 cell line in vitro. Results: When hyperthermia was combined with chemotherapy, the median lethal dose (LD50) was equivalent regardless of the duration of exposure, and was independent of the exposure temperature. Taxanes showed a similar LD50 over the temperature range tested. Conclusions: In our study, hyperthermia does not increase the cytotoxic effects of taxanes, at least for the concentrations and durations tested. Copyright (C) 2011 S. Karger AG, Basel
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页码：55 / 63
页数：9
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