Protein detection with aptamer biosensors

被引:183
作者
Strehlitz, Beate [1 ]
Nikolaus, Nadia [1 ]
Stoltenburg, Regina [1 ]
机构
[1] UFZ Helmholtz Ctr Environm Res, UBZ, D-04318 Leipzig, Germany
关键词
aptamer; protein; biosensor; SELEX;
D O I
10.3390/s8074296
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Aptamers have been developed for different applications. Their use as new biological recognition elements in biosensors promises progress for fast and easy detection of proteins. This new generation of biosensor (aptasensors) will be more stable and well adapted to the conditions of real samples because of the specific properties of aptamers.
引用
收藏
页码:4296 / 4307
页数:12
相关论文
共 35 条
[1]   Aptasensor development: Elucidation of critical parameters for optimal aptamer performance [J].
Baldrich, E ;
Restrepo, A ;
O'Sullivan, CK .
ANALYTICAL CHEMISTRY, 2004, 76 (23) :7053-7063
[2]   A novel electrochemical detection method for aptamer biosensors [J].
Bang, GS ;
Cho, S ;
Kim, BG .
BIOSENSORS & BIOELECTRONICS, 2005, 21 (06) :863-870
[3]   SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN [J].
BOCK, LC ;
GRIFFIN, LC ;
LATHAM, JA ;
VERMAAS, EH ;
TOOLE, JJ .
NATURE, 1992, 355 (6360) :564-566
[4]   Aptamer-based biosensors for label-free voltammetric detection of lysozyme [J].
Cheng, Alan K. H. ;
Ge, Bixia ;
Yu, Hua-Zhong .
ANALYTICAL CHEMISTRY, 2007, 79 (14) :5158-5164
[5]   INVITRO SELECTION OF RNA MOLECULES THAT BIND SPECIFIC LIGANDS [J].
ELLINGTON, AD ;
SZOSTAK, JW .
NATURE, 1990, 346 (6287) :818-822
[6]   Quantum-dot/aptamer-based ultrasensitive multi-analyte electrochemical biosensor [J].
Hansen, JA ;
Wang, J ;
Kawde, AN ;
Xiang, Y ;
Gothelf, KV ;
Collins, G .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (07) :2228-2229
[7]   Novel electrochemical sensor system for protein using the aptamers in sandwich manner [J].
Ikebukuro, K ;
Kiyohara, C ;
Sode, K .
BIOSENSORS & BIOELECTRONICS, 2005, 20 (10) :2168-2172
[8]  
Jayasena SD, 1999, CLIN CHEM, V45, P1628
[9]   HIGH-RESOLUTION MOLECULAR DISCRIMINATION BY RNA [J].
JENISON, RD ;
GILL, SC ;
PARDI, A ;
POLISKY, B .
SCIENCE, 1994, 263 (5152) :1425-1429
[10]  
Kubik MF, 1997, J IMMUNOL, V159, P259