Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma

被引：112

作者：

Guo, Weijie ^{[1
,2
]}

Zhao, Yingjun ^{[1
]}

Zhang, Zhenfeng ^{[1
]}

Tan, Ning ^{[1
]}

Zhao, Fangyu ^{[1
]}

Ge, Chao ^{[1
]}

Liang, Linhui ^{[1
]}

Jia, Deshui ^{[1
,2
]}

Chen, Taoyang ^{[4
]}

Yao, Ming ^{[1
,3
]}

Li, Jinjun ^{[1
]}

He, Xianghuo ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Canc Inst, Renji Hosp, State Key Lab Oncogenes & Related Genes,Sch Med, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Canc Inst, Renji Hosp, Lab Expt Pathol,Sch Med, Shanghai 200032, Peoples R China

[4] Qi Dong Liver Canc Inst, Qi Dong 226200, Jiangsu, Peoples R China

来源：

CANCER LETTERS | 2011年 / 312卷 / 01期

基金：

中国国家自然科学基金;

关键词：

xCT; ROS; Autophagy; Tumorigenecity; Hepatocellular carcinoma; AMINO-ACID TRANSPORTERS; CYSTINE UPTAKE; GLUTATHIONE LEVELS; SYSTEM X(C)(-); CANCER CELLS; GLUTAMATE; SULFASALAZINE; THERAPY; REQUIREMENT; MACROPHAGES;

D O I：

10.1016/j.canlet.2011.07.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

xCT, the functional subunit of the system x(c)(-) which plays an important role in maintaining intracellular glutathione (GSH) levels, is expressed in various malignant tumors. Here, we demonstrated that xCT expression is often elevated in HCC and is associated with poor prognosis in HCC patients; moreover, disruption of xCT suppressed HCC cell growth both in vitro and in vivo. xCT dysfunction has also been shown to increase intracellular reactive oxygen species (ROS) levels, thus in turn led to autophagic cell death of HCC cells. Taken together, these findings suggest that xCT may be a promising therapeutic target for human HCC. (C) 2011 Published by Elsevier Ireland Ltd.

引用

页码：55 / 61

页数：7

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