A Comparison of Multimodality Treatment: Two and Four Courses of Neoadjuvant Chemotherapy Using S-1/CDDP or S-1/CDDP/Docetaxel Followed by Surgery and S-1 Adjuvant Chemotherapy for Macroscopically Resectable Serosa-positive Gastric Cancer: A Randomized Phase II Trial (COMPASS-D Trial)

被引：14

作者：

Yoshikawa, Takaki ^{[1
]}

Taguri, Masataka ^{[2
]}

Sakuramoto, Shinichi ^{[3
]}

Kunisaki, Chikara ^{[4
]}

Fukunaga, Tetsu ^{[5
]}

Ito, Seiji ^{[6
]}

Cho, Haruhiko

Tanabe, Kazuaki ^{[7
]}

Nishikawa, Kazuhiro ^{[8
]}

Matsui, Takanori ^{[9
]}

Morita, Satoshi ^{[2
]}

Tsuburaya, Akira

机构：

[1] Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Asahi Ku, Yokohama, Kanagawa 2410815, Japan

[2] Yokohama City Univ, Med Ctr, Dept Biostat & Epidemiol, Yokohama, Kanagawa 232, Japan

[3] Kitasato Univ, Dept Surg, Sagamihara, Kanagawa 228, Japan

[4] Yokohama City Univ, Med Ctr, Dept Surg, Yokohama, Kanagawa 232, Japan

[5] St Marianna Univ, Dept Gastroenterol & Gen Surg, Kawasaki, Kanagawa, Japan

[6] Aichi Canc Ctr Hosp, Dept Surg Gastroenterol, Nagoya, Aichi 464, Japan

[7] Hiroshima Univ, Dept Gastrointestinal Surg, Hiroshima, Japan

[8] Osaka Gen Med Ctr, Dept Surg, Osaka, Japan

[9] Aichi Hosp, Aichi Canc Ctr, Dept Gastrointestinal Surg, Okazaki, Aichi, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2012年 / 42卷 / 01期

关键词：

gastric; neoadjuvant chemotherapy; Phase II; cancer; PLUS CISPLATIN; PERIOPERATIVE CHEMOTHERAPY; PACLITAXEL; MULTICENTER; ADENOCARCINOMA; THERAPY;

D O I：

10.1093/jjco/hyr166

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This randomized Phase II trial will compare the outcome of neoadjuvant chemotherapy using two and four courses of S-1 plus cisplatin or S-1 plus cisplatin plus docetaxel by a two-by-two factorial design for patients with macroscopically resectable serosa-positive gastric cancer. After neoadjuvant chemotherapy, patients will receive D2 gastrectomy followed by S-1 chemotherapy for 1 year postoperatively. The primary endpoint is the 3-year overall survival. The sample size is 120 for the two hypotheses: the superiority of four courses compared with two courses and the superiority of S-1 plus cisplatin plus docetaxel compared with S-1 plus cisplatin. This trial will be able to define the more suitable number of cycles and better regimen of neoadjuvant chemotherapy for gastric cancer.

引用

页码：74 / 77

页数：4

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