Perisomatic inhibition and cortical circuit dysfunction in schizophrenia

被引：63

作者：

Lewis, David A. ^{[1
]}

Fish, Kenneth N. ^{[1
]}

Arion, Dominique ^{[1
]}

Gonzalez-Burgos, Guillermo ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Psychiat, Translat Neurosci Program, Pittsburgh, PA 15261 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2011年 / 21卷 / 06期

关键词：

DORSOLATERAL PREFRONTAL CORTEX; GLUTAMIC-ACID DECARBOXYLASE; GAMMA-AMINOBUTYRIC-ACID; FAST-SPIKING INTERNEURONS; COGNITIVE CONTROL; HIPPOCAMPAL INTERNEURONS; NETWORK OSCILLATIONS; SYNAPTIC ACTIVATION; TONIC INHIBITION; PYRAMIDAL CELLS;

D O I：

10.1016/j.conb.2011.05.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Deficits of cognitive control in schizophrenia are associated with altered gamma oscillations in the prefrontal cortex. Paralbumin basket interneurons, which innervate the perisomatic region of pyramidal neurons, appear to play a key role in generating cortical gamma oscillations. In the prefrontal cortex of subjects with schizophrenia, alterations are present in both pre- and post-synaptic markers of the strength of GABA inputs from parvalbumin basket neurons to pyramidal neurons. These alterations may contribute to the neural substrate for impaired gamma oscillations in schizophrenia.

引用

页码：866 / 872

页数：7

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