Precise determination of 2-deoxy-D-ribose internal energies after keV proton collisions

被引：33

作者：

Alvarado, Fresia ^{[1
]}

Bernard, Jerome ^{[2
]}

Li, Bin ^{[2
]}

Bredy, Richard ^{[2
]}

Chen, Li ^{[2
]}

Hoekstra, Ronnie ^{[1
]}

Martin, Serge ^{[2
]}

Schlatholter, Thomas ^{[1
]}

机构：

[1] Univ Groningen, KVI Atom Phys, NL-9747 AA Groningen, Netherlands

[2] Univ Lyon 1, CNRS, LASIM, UMR 5579, F-69622 Villeurbanne, France

来源：

CHEMPHYSCHEM | 2008年 / 9卷 / 09期

关键词：

DNA damage; fragmentation reactions; gas-phase reactions; ions; mass spectrometry;

D O I：

10.1002/cphc.200800110

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

(Figure Presented) DNA fragmentation: Proton irradiation (see picture) can lead to complex DNA strand breaks at the sugar-phosphate backbone. Precise measurements of the excitation energy of transient deoxyribose dications after proton collisions at Bragg-peak energies are reported. The breakup patterns seem to be independent of the excitation energy, suggesting a statistical fragmentation mechanism. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1254 / 1258

页数：5

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