Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers

被引：207
作者：
Kozminski, Przemyslaw [1 ]
Halik, Pawel Krzysztof [1 ]
Chesori, Raphael [1 ]
Gniazdowska, Ewa [1 ]
机构：
[1] Inst Nucl Chem & Technol, Ctr Radiochem & Nucl Chem, Dorodna 16, PL-03195 Warsaw, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 10期
关键词：
methotrexate; myasthenia gravis; Alzheimer's disease; immunosuppressive drug; disease modifying anti-rheumatic drug; anticancer drug; HIGH-DOSE METHOTREXATE; CENTRAL-NERVOUS-SYSTEM; ACUTE LYMPHOBLASTIC-LEUKEMIA; SINGLE-AGENT METHOTREXATE; SQUAMOUS-CELL CARCINOMA; NEGATIVE BREAST-CANCER; GESTATIONAL TROPHOBLASTIC NEOPLASIA; TREAT MYCOSIS-FUNGOIDES; ADVANCED BLADDER-CANCER; BLOOD-BRAIN-BARRIER;
D O I：
10.3390/ijms21103483
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune diseases. In this paper, we take an overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy. In addition, the issue of the potential benefits of methotrexate in the development of neurological disorders in Alzheimer's disease or myasthenia gravis will be discussed.
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页数：38
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