A positive feed-forward loop between Fusobacterium nucleatum and ethanol metabolism reprogramming drives laryngeal cancer progression and metastasis

被引：26

作者：

Hsueh, Chi-Yao ^{[1
]}

Huang, Qiang ^{[1
]}

Gong, Hongli ^{[1
]}

Shen, Yujie ^{[1
]}

Sun, Ji ^{[2
]}

Lau, Hui-Ching ^{[1
]}

Zhang, Duo ^{[1
]}

Tang, Di ^{[1
]}

Wu, Chunping ^{[1
]}

Guo, Yang ^{[1
]}

Huang, Huiying ^{[1
]}

Cao, Pengyu ^{[1
]}

Tao, Lei ^{[1
]}

Zhang, Ming ^{[1
]}

Zhou, Liang ^{[1
]}

机构：

[1] Fudan Univ, Eye & ENT Hosp, Dept Otorhinolaryngol, 83 Fen Yang Rd, Shanghai 200031, Peoples R China

[2] Fudan Univ, Eye & ENT Hosp, Dept Pathol, 83 Fen Yang Rd, Shanghai 200031, Peoples R China

来源：

ISCIENCE | 2022年 / 25卷 / 02期

基金：

中国国家自然科学基金;

关键词：

ALCOHOL-CONSUMPTION; COLORECTAL-CANCER; NECK-CANCER; HEAD; PROMOTES; CARCINOGENESIS; EXPRESSION; RISK; MICE;

D O I：

10.1016/j.isci.2022.103829

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alcohol consumption, which affects the structure and composition of the laryngeal microbiota, is one of the most important risk factors for laryngeal squamous cell cancer (LSCC). Our results demonstrated that high enrichment of Fusobacterium nucleatum (F. nucleatum) in LSCC was associated with poor prognosis. F. nucleatum increased miR-155-5p and miR-205-5p expression to suppress alcohol dehydrogenase 1B (ADH1B) and transforming growth factor b receptor 2 (TGFBR2) expression by activating innate immune signaling, resulting in ethanol metabolism reprogramming to allow F. nucleatum accumulation and PI3K/AKT signaling pathway activation to promote epithelial-mesenchymal transition, further exacerbating the uncontrolled progression and metastasis of LSCC. Therefore, the positive feed-forward loop between F. nucleatum and ethanol metabolism reprogramming promotes cell proliferation, migration, and invasion to affect LSCC patient prognosis. The amount of F. nucleatum is a potential prognostic biomarker, which yields valuable insight into clinical management that may improve the oncologic outcome of patients with LSCC.

引用

页数：22

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