The Therapeutic Potential of Rutin for Diabetes: An Update

被引：60

作者：

Habtemariam, Solomon ^{[1
]}

Lentini, Giovanni ^{[2
]}

机构：

[1] Univ Greenwich, Medway Sch Sci, Pharmacognosy Res Labs, Chatham ME4 4TB, Kent, England

[2] Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, I-70125 Bari, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2015年 / 15卷 / 07期

关键词：

Rutin; diabetes; anti-inflammatory; antioxidant; organ protection; multifunctional compound; GLUCOSE-UPTAKE; INSULIN-RESISTANCE; OXIDATIVE STRESS; QUERCETIN; ALPHA; INFLAMMATION; ABSORPTION; INHIBITION; FLAVONOIDS; CELLS;

D O I：

10.2174/138955751507150424103721

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diabetes and its major risk factor, obesity, have become a world-wide epidemic and cause of suffering for millions of people. There is still no drug of cure for diabetes and the currently available drugs suffer from a number of limitations either due to side effects and/or loss of efficacy during prolonged use. Rutin is one of the most abundant polyphenolic compounds belonging to the flavonoid class. In the present communication, its therapeutic potential for diabetes is critically analysed by reviewing its effect on the various targets of diabetes. The multifunctional nature of rutin including action via antioxidant, anti-inflammatory, organoprotection, etc., mechanisms is outlined through review of evidences from in vitro and in vivo studies.

引用

页码：524 / 528

页数：5

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