The chemistry of 2-aminocycloalkanecarboxylic acids

被引：356
作者：
Fülöp, F [1 ]
机构：
[1] Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary
来源：
CHEMICAL REVIEWS | 2001年 / 101卷 / 07期
关键词：
D O I：
10.1021/cr000456z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis and transformations of 2-aminocycloalkanecarboxylic acids were discussed. The resolution of the racemates by diastereomer separation and biocatalyzed transformations were studied. It was found that the selective reductive aminations of β-ketoesters via enamines resulted into the accurate ratios of cis and trans diastereomers. The synthesis of 2-aminocycloalkanecarboxylic acids from 1,2-dicarboxylic acids derivatives by rearrangements was also elaborated.
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页码：2181 / 2204
页数：24
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