Constituents from Chimonanthus praecox (wintersweet)

被引：50

作者：

Wang, Wen-Xuan ^{[1
,2
]}

Cao, Lei ^{[1
,2
]}

Xiong, Juan ^{[3
]}

Xia, Gang ^{[1
,2
]}

Hu, Jin-Feng ^{[1
,2
,3
]}

机构：

[1] E China Normal Univ, Dept Nat Prod Chem Genet Res, Key Lab Brain Funct Genom, Minist Educ, Shanghai 200062, Peoples R China

[2] E China Normal Univ, Shanghai Key Lab Brain Funct Genom MOE & SBFG, Shanghai 200062, Peoples R China

[3] Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2011年 / 4卷 / 03期

关键词：

Chimonanthus praecox; Calycanthaceae; Sesquiterpenoids; Dimeric tryptamine-related alkaloids; HOMALOMENA-AROMATICA; SESQUITERPENE; ALKALOIDS; LEAVES; TRITERPENOIDS; MEGASTIGMANE; GLUCOSIDES; GLYCOSIDES; ALCOHOL; BENZYL;

D O I：

10.1016/j.phytol.2011.04.012

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One new (1) and seven (2-8) known sesquiterpenoids, four dimeric tryptamine-related alkaloids (9-12) and six glycosides (13-18) were isolated from the fruits and leaves of Chimonanthus praecox (wintersweet). Based on its spectroscopic data, the new structure of compound 1, an oppositane-type sesquiterpenoid, was elucidated to be the C-4 epimer of bullatantriol (2). All isolated compounds were evaluated for their cytotoxicities against a small panel of human cancer cell lines, and only the chimonanthine-type alkaloids (10-12) were found to have cytotoxic effects against gastric carcinoma NUGC3 and hepatocarcinoma SNU739 cancer cells, with IC50 values ranging from 10.3 to 19.7 mu M. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：271 / 274

页数：4

共 26 条

[1] A NEW SESQUITERPENE ALCOHOL FROM PTEROCARPUS-MARSUPIUM
ADINARAYANA, D
SYAMASUNDAR, KV
[J]. PHYTOCHEMISTRY, 1982, 21 (05) : 1083 - 1085
[2] CYTO-TOXICITY ON HUMAN-LEUKEMIC AND RAT HEPATOMA-CELL LINES OF ALKALOID EXTRACTS OF PSYCHOTRIA-FORSTERIANA
ADJIBADE, Y
KUBALLA, B
CABALION, P
JUNG, ML
BECK, JP
ANTON, R
[J]. PLANTA MEDICA, 1989, (06) : 567 - 588
[3] METHYL-1-(BETA-D-GLUCOPYRANOSYL)-3-INDOLEACETATE
FRANKLIN, RL
SELL, HM
[J]. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1969, 14 (02) : 267 - &
[4] Chemical synthesis of hydroxycinnamic acid glucosides and evaluation of their ability to stabilize natural Colors via anthocyanin copigmentation
Galland, Stephanie
Mora, Nathalie
Abert-Vian, Maryline
Rakotomanomana, Njara
Dangles, Olivier
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (18) : 7573 - 7579
[5] (S)-LINALYL, 2-PHENYLETHYL, AND BENZYL DISACCHARIDE GLYCOSIDES ISOLATED AS AROMA PRECURSORS FROM OOLONG TEA LEAVES
GUO, WF
HOSOI, R
SAKATA, K
WATANABE, N
YAGI, A
INA, K
LUO, SJ
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1994, 58 (08) : 1532 - 1534
[6] SESQUITERPENE ALCOHOLS AND TRITERPENOIDS FROM LIATRIS-MICROCEPHALA
HERZ, W
WATANABE, K
[J]. PHYTOCHEMISTRY, 1983, 22 (06) : 1457 - 1459
[7] *JIANGS NEW MED CO, 1986, DICT CHIN MAT MED, P1863
[8] Two new tryptamine-derived alkaloids from Chimonanthus praecox L concolor
Kitajima, M
Mori, I
Arai, K
Kogure, N
Takayama, H
[J]. TETRAHEDRON LETTERS, 2006, 47 (19) : 3199 - 3202
[9] THE CONSTITUTION OF LINOCINNAMARIN
KLOSTERMAN, HJ
SMITH, F
CLAGETT, CO
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (02) : 420 - 421
[10] NON-VOLATILE CONSTITUENTS IN TOBACCO .1. ISOLATION OF A NEW TERPENE GLUCOSIDE, 3-HYDROXY-5,6-EPOXY-BETA-IONYL-BETA-D-GLUCOPYRANOSIDE FROM FLUE-CURED TOBACCO
KODAMA, H
FUJIMORI, T
KATO, K
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1981, 45 (04): : 941 - 944

← 1 2 3 →