Transcription by RNA polymerase II and the CTD-chromatin crosstalk

被引：13

作者：

Singh, Neha ^{[1
]}

Asalam, Mohd ^{[1
]}

Ansari, Mohd Owais ^{[1
]}

Gerasimova, Nadezhda S. ^{[2
]}

Studitsky, Vasily M. ^{[2
]}

Akhtar, Md Sohail ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Biochem & Struct Biol Div, Lucknow, Uttar Pradesh, India

[2] Lomonosov Moscow State Univ, Sch Biol, Dept Bioengn, Moscow, Russia

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2022年 / 599卷

基金：

俄罗斯科学基金会;

关键词：

Transcription; RNA polymerase II; CTD; Chromatin; Kinases; C-TERMINAL DOMAIN; PHOSPHORYLATION; RECRUITMENT; ELONGATION; KINASE; PHOSPHATASE; THREONINE-4; ISOMERASE; SAGA; SEN1;

D O I：

10.1016/j.bbrc.2022.02.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epigenetic phenomenon is known to derive the phenotypic variation of an organism through an interconnected cellular network of histone modifications, DNA methylation and RNA regulatory network. Transcription for protein coding genes is a highly regulated process and carried out by a large multi-complex RNA Polymerase II. The carboxy terminal domain (CTD) of the largest subunit of RNA Poly-merase II consists of a conserved and highly repetitive heptad sequence Tyr(1)-Ser(2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)- Ser(7). The epigenetically modified CTD is thought to selectively bind different protein complexes that participate in mRNA biogenesis and export. The CTD and chromatin appears to have a spatial relationship during the transcription cycle, where the epigenetic modifications of CTD not only influence the state of histone modification but also mediates CTD-chromatin crosstalk. In this mini review, we have surveyed and discussed current developments of RNA Polymerase II CTD and its new emerging crosstalk with chromatin, during the stage specific progression of RNA Polymerase II in transcription cycle. This review is mainly focussed on the insights in budding yeast. (c) 2022 Elsevier Inc. All rights reserved.

引用

页码：81 / 86

页数：6

共 60 条

[1] The Set1 N-terminal domain and Swd2 interact with RNA polymerase II CTD to recruit COMPASS [J].

Bae, Hyun Jin ;

Dubarry, Marion ;

Jeon, Jongcheol ;

Soares, Luis M. ;

Dargemont, Catherine ;

Kim, Jaehoon ;

Geli, Vincent ;

Buratowski, Stephen .

NATURE COMMUNICATIONS, 2020, 11 (01)

[2] A Universal RNA Polymerase II CTD Cycle Is Orchestrated by Complex Interplays between Kinase, Phosphatase, and Isomerase Enzymes along Genes [J].

Bataille, Alain R. ;

Jeronimo, Celia ;

Jacques, Pierre-Etienne ;

Laramee, Louise ;

Fortin, Marie-Eve ;

Forest, Audrey ;

Bergeron, Maxime ;

Hanes, Steven D. ;

Robert, Francois .

MOLECULAR CELL, 2012, 45 (02) :158-170

[3] RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases [J].

Battaglia, Sofia ;

Lidschriber, Michael ;

Baejen, Carlo ;

Torkler, Phillip ;

Vos, Seychelle M. ;

Cramer, Patrick .

ELIFE, 2017, 6

[4] Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp [J].

Bernecky, Carrie ;

Plitzko, Juergen M. ;

Cramer, Patrick .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2017, 24 (10) :809-+

[5] Monochromatic X-Ray Induced Novel Synthesis of Plasmonic Nanostructure for Photovoltaic Application [J].

Bharti, Amardeep ;

Bhardwaj, Richa ;

Agrawal, Ashish K. ;

Goyal, Navdeep ;

Gautam, Sanjeev .

SCIENTIFIC REPORTS, 2016, 6

[6] Progression through the RNA Polymerase II CTD Cycle [J].

Buratowski, Stephen .

MOLECULAR CELL, 2009, 36 (04) :541-546

[7] Interactions of Sen1, Nrd1, and Nab3 with Multiple Phosphorylated Forms of the Rpb1 C-Terminal Domain in Saccharomyces cerevisiae [J].

Chinchilla, Karen ;

Rodriguez-Molina, Juan B. ;

Ursic, Doris ;

Finkel, Jonathan S. ;

Ansari, Aseem Z. ;

Culbertson, Michael R. .

EUKARYOTIC CELL, 2012, 11 (04) :417-429

[8] Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP [J].

Chiu, Anthony C. ;

Suzuki, Hiroshi I. ;

Wu, Xuebing ;

Mahat, Dig B. ;

Kriz, Andrea J. ;

Sharp, Phillip A. .

MOLECULAR CELL, 2018, 69 (04) :648-+

[9] RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and Template [J].

Corden, Jeffry L. .

CHEMICAL REVIEWS, 2013, 113 (11) :8423-8455

[10] Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets [J].

Cossa, Giacomo ;

Parua, Pabitra K. ;

Eilers, Martin ;

Fisher, Robert P. .

GENES & DEVELOPMENT, 2021, 35 (9-10) :658-676

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