Adherence to Highly Active Antiretroviral Therapy (HAART): A Meta-Analysis

被引：255

作者：

Ortego, Carmen ^{[1
]}

Huedo-Medina, Tania B. ^{[2
]}

Llorca, Javier ^{[3
,4
,5
]}

Sevilla, Lourdes ^{[1
]}

Santos, Pilar ^{[1
]}

Rodriguez, Elias ^{[1
]}

Warren, Michelle R. ^{[2
]}

Vejo, Javier ^{[1
]}

机构：

[1] Univ Cantabria, Dept Nursing, Santander, Spain

[2] Univ Connecticut, CHIP, Storrs, CT USA

[3] Univ Cantabria, Grp Epidemiol & Computat Biol, Cantabria, Spain

[4] CIBERESP, Barcelona, Spain

[5] IFIMAV, Santander, Spain

来源：

AIDS AND BEHAVIOR | 2011年 / 15卷 / 07期

关键词：

HAART; Acquired immunodeficiency syndrome; HIV; Adherence; Meta-analysis; Human development; HIV-INFECTED PATIENTS; DRUG-RESISTANCE MUTATIONS; SELF-REPORTED ADHERENCE; VIROLOGICAL TREATMENT RESPONSE; QUALITY-OF-LIFE; PATIENT ADHERENCE; PUBLICATION BIAS; TREATMENT SATISFACTION; MEDICATION ADHERENCE; CLINICAL PROGRESSION;

D O I：

10.1007/s10461-011-9942-x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This meta-analysis synthesizes eighty-four observational studies, conducted across twenty countries, to determine the mean proportion of people who reported >= 90% adherence to prescribed highly active antiretroviral therapy (HAART) and to identify the factors associated with high levels of adherence. Eight electronic databases were searched to locate all relevant studies available by January 2010, which were then coded for sample characteristics and adherence levels. The average rate of reporting >= 90% adherent HAART adherence is 62%. However, this proportion varies greatly across studies. In particular, a greater proportion of individuals maintaining >= 90% adherence to HAART is more likely in studies with higher proportions of men who have sex with men (MSM) and lower proportions of injection drug users (IDU), with participants in an earlier stage of infection, and in studies conducted in countries characterized by lower Human Development Index (HDI) scores.

引用

页码：1381 / 1396

页数：16

共 130 条

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