Classification of adult-type diffuse gliomas: Impact of the World Health Organization 2021 update

被引：88

作者：

Whitfield, Benjamin T. ^{[1
]}

Huse, Jason T. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Pathol, 2130 W Holcombe Blvd,LSP9-4009,Unit 2951, Houston, TX 77030 USA

来源：

BRAIN PATHOLOGY | 2022年 / 32卷 / 04期

关键词：

astrocytoma; glioblastoma; glioma; IDH; oligodendroglioma; TERT PROMOTER MUTATIONS; INTRATUMORAL HETEROGENEITY; GENETIC ALTERATIONS; IDH2; MUTATIONS; ATRX; GRADE; OLIGODENDROGLIOMA; TUMORS; FUBP1; PROTEIN;

D O I：

10.1111/bpa.13062

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Over the last decade, developments in molecular profiling have radically altered the diagnosis, classification, and management of numerous cancer types, with primary brain tumors being no exception. Although historically brain tumors have been classified based on their morphological characteristics, recent advances have allowed refinement of tumor classification based on molecular alterations. This shift toward molecular classification of primary brain tumors is reflected in the 2021 5(th) edition of the WHO classification of central nervous system tumors (WHO 2021). In this review, we will discuss the most recent updates to the classification of adult-type diffuse gliomas, a group of highly infiltrative and largely incurable CNS malignancies. It is our hope continued that refinement of molecular criteria will improve diagnosis, prognostication, and eventually treatment of these devastating tumors.

引用

页数：12

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