Thermoresponsive polymers as promising new materials for local radiotherapy

被引：39

作者：

Hruby, M

Subr, V

Kucka, J

Kozempel, J

Lebeda, O

Sikora, A

机构：

[1] Acad Sci Czech Republ, Inst Macromol Chem, CR-16206 Prague, Czech Republic

[2] Charles Univ, Fac Sci, Dept Organ & Nucl Chem, Prague 12843, Czech Republic

[3] Acad Sci Czech Republ, Inst Nucl Phys, CZ-25068 Rez, Czech Republic

来源：

APPLIED RADIATION AND ISOTOPES | 2005年 / 63卷 / 04期

关键词：

thermoresponsive; polymer; poly(N-isopropyl acrylamide); DTPA; tyrosinamide; local radiotherapy; yttrium-90; iodine-125;

D O I：

10.1016/j.apradiso.2005.05.043

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We describe a novel thermoresponsive polymeric drug delivery system based on poly(N-isopropylacrylamide) with isotopically labellable end groups [L-tyrosinamide or diethylenetriaminepentaacetic acid (DTPA)] designed for local radiotherapy. The polymers are readily soluble in isotonic aqueous sodium chloride at room temperature and the phase separation is complete at body temperature as proved by DSC measurements. Sufficent binding capacity for radionuclides and chemical stability are demonstrated on I-125 and Y-90-labelled polymers. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：423 / 431

页数：9

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