Zwitterionic capsular polysaccharides: the new MHCII-dependent antigens

被引：71
作者：
Cobb, BA
Kasper, DL [1 ]
机构：
[1] Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA USA
来源：
CELLULAR MICROBIOLOGY | 2005年 / 7卷 / 10期
关键词：
D O I：
10.1111/j.1462-5822.2005.00591.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The immune system has evolved the ability for T cells to recognize nearly any biological polymer, including peptides, protein superantigens, and glycolipids through presentation by the major histocompatibility complex (MHC) proteins such as MHC class I (MHCI), MHC class II (MHCII), and CD1. A recent and unexpected addition to this list is the zwitterionic capsular polysaccharide (ZPS). These bacterial molecules utilize MHCII presentation to activate T cells via recognition by alpha beta T cell receptor (alpha beta TCR) proteins. In this review, we explore what is currently known about ZPS processing and presentation within antigen-presenting cells (APCs) and the immune response that follows.
引用
收藏
页码：1398 / 1403
页数：6
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