Synthesis and Cytotoxicity Studies of Novel 2-Hydrazonylpyrido[2,3-b]pyrazin-3(4H)-ones

被引：6

作者：

Zhang, Guogang ^{[1
]}

Liu, Yajing ^{[1
]}

Wang, Shuobing ^{[1
]}

Zhou, Chuan ^{[1
]}

Huang, Qingchang ^{[1
]}

Gong, Ping ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Original New Drugs Design & Discovery, Minist Educ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China

来源：

ARCHIV DER PHARMAZIE | 2012年 / 345卷 / 01期

关键词：

Anticancer activity; Apoptosis; 2-Hydrazonylpyrido[2; 3-b]pyrazin-3(4H)-ones; APOPTOSIS; CALPAIN;

D O I：

10.1002/ardp.201100103

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In an attempt to develop potent antitumor agents, a series of novel 2-hydrazonylpyrido[2,3-b]pyrazin-3(4H)-one derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro. Pharmacological data indicated that five of the target compounds showed cytotoxicity against A549 cell line below a concentration of 1 mu M. Compound 15g was the most potent one with IC50 values of 0.19, 2.11 and 2.15 mu M against A549, MDA-MB-231 and HT29 cell lines, respectively.

引用

页码：49 / 56

页数：8

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