The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, lovastatin (statin) ameliorates CCK-induced acute pancreatitis in rats

被引：11
|
作者：
Choi, OS
Park, SJ
Seo, SW
Park, CS
Cho, JJ
Ahn, HJ
机构：
[1] Kyung Hee Univ, Coll Med, Dept Microbiol, Seoul 130701, South Korea
[2] Kyung Hee Univ, Dept Pharmacol, Coll Oriental Med, Seoul 130701, South Korea
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2005年 / 28卷 / 08期
关键词：
statin; anti-inflammatory effect; acute pancreatitis;
D O I：
10.1248/bpb.28.1394
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Statin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has an anti-inflammatory effect. The aim of this study was to investigate the effect of Lovastatin (statin) on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats. In statin treated group, the pancreas weight/body weight (pw/bw) ratio in CCK-induced acute pancreatitis was significantly lower than DMSO-treated group. Statin also increased the pancreatic level of HSP 60. Additionally, the secretions of IL-1 beta, TNF-alpha and IL-6 and the lipase levels were decreased in statin treated group. These results suggest that statin may play an important role in mitigating the. progression of the inflammatory reactions during acute pancreatitis.
引用
收藏
页码：1394 / 1397
页数：4
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