Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization

被引：36

作者：

Huang, Jiahn-Dar ^{[1
]}

Amaral, Juan ^{[1
]}

Lee, Jung Wha ^{[1
]}

Larrayoz, Ignacio M. ^{[1
,2
]}

Rodriguez, Ignacio R. ^{[1
]}

机构：

[1] NEI, NIH, Sect Mech Retinal Dis, LRCMB, Bethesda, MD 20892 USA

[2] Ctr Biomed Res La Rioja CIBIR, Angiogenesis Unit, La Rioja, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2012年 / 1821卷 / 04期

关键词：

ER stress; 7-ketocholesterol; Inflammation; Sterculic acid; CHOP; RPE;

D O I：

10.1016/j.bbalip.2012.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sterculic acid is a cyclopropene fatty acid with numerous biological activities. In this study we demonstrate that sterculic acid is a potent inhibitor of endoplasmic reticulum (ER) stress and related inflammation caused by 7-ketocholesterol (7KCh). 7KCh is a highly toxic oxysterol suspected in the pathogenesis of various age-related diseases such as atherosclerosis, Alzheimer's disease and age-related macular degeneration. Sterculic acid demonstrated to be 5-10 times more effective than other anti-inflammatory fatty acids at inhibiting 7KCh-mediated inflammatory responses in cultured cells. In vivo, sterculic acid was effective at inhibiting the formation of choroidal neovascularization (CNV) in the laser-injury rat model. Our data suggests that sterculic acid may be useful in treating CNV in certain forms of age-related macular degeneration. Published by Elsevier B.V.

引用

页码：637 / 646

页数：10

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