In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML

被引：38
作者：
Liso, A. [1 ]
Bogliolo, A. [2 ]
Freschi, V. [2 ]
Martelli, M. P. [3 ]
Pileri, S. A. [4 ]
Santodirocco, M. [1 ]
Bolli, N. [5 ]
Martelli, M. F. [5 ]
Falini, B. [5 ]
机构：
[1] Univ Foggia, Inst Haematol, Dept Med & Occupat Sci, Foggia, Italy
[2] Univ Urbino, ISTI, I-61029 Urbino, Italy
[3] Univ Bari, Inst Haematol, Bari, Italy
[4] Univ Bologna, Policlin S Orsola, Inst Haematol, Haematopathol Unit, Bologna, Italy
[5] Univ Perugia, Inst Haematol, I-06100 Perugia, Italy
来源：
LEUKEMIA | 2008年 / 22卷 / 06期
关键词：
D O I：
10.1038/sj.leu.2405045
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
[No abstract available]
引用
收藏
页码：1285 / 1289
页数：5
相关论文
共 13 条
[1]   Identification and functional characterization of a cytoplasmic nucleophosmin leukaemic mutant generated by a novel exon-11 NPM1 mutation [J].
Albiero, E. ;
Madeo, D. ;
Bolli, N. ;
Giaretta, I. ;
Di Bona, E. ;
Martelli, M. F. ;
Nicoletti, I. ;
Rodeghiero, F. ;
Falini, B. .
LEUKEMIA, 2007, 21 (05) :1099-1103
[2]   Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants [J].
Bolli, Niccolo ;
Nicoletti, Ildo ;
De Marco, M. Felicetta ;
Bigerna, Barbara ;
Pucciarini, Alessandra ;
Mannucci, Roberta ;
Martelli, Maria Paola ;
Liso, Arcangelo ;
Mecucci, Cristina ;
Fabbiano, Francesco ;
Martelli, Massimo F. ;
Henderson, Beric R. ;
Falini, Brunangelo .
CANCER RESEARCH, 2007, 67 (13) :6230-6237
[3]   Coding repeats and evolutionary "agility" [J].
Caburet, S ;
Cocquet, J ;
Vaiman, D ;
Veitia, RA .
BIOESSAYS, 2005, 27 (06) :581-587
[4]  
DARVASI A, 1995, EUR J HUM GENET, V3, P14
[5]   Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. [J].
Falini, B ;
Mecucci, C ;
Tiacci, E ;
Alcalay, M ;
Rosati, R ;
Pasqualucci, L ;
La Starza, R ;
Diverio, D ;
Colombo, E ;
Santucci, A ;
Bigerna, B ;
Pacini, R ;
Pucciarini, A ;
Liso, A ;
Vignetti, M ;
Fazi, P ;
Meani, N ;
Pettirossi, V ;
Saglio, G ;
Mandelli, F ;
Lo-Coco, F ;
Pelicci, P ;
Martelli, MF .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (03) :254-266
[6]   Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML):: biologic and clinical features [J].
Falini, Brunangelo ;
Nicoletti, Ildo ;
Martelli, Massimo F. ;
Mecucci, Cristina .
BLOOD, 2007, 109 (03) :874-885
[7]   Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML [J].
Falini, Brunangelo ;
Bolli, Niccolò ;
Shan, Jing ;
Martelli, Maria Paola ;
Liso, Arcangelo ;
Pucciarini, Alessandra ;
Bigerna, Barbara ;
Pasqualucci, Laura ;
Mannucci, Roberta ;
Rosati, Roberto ;
Gorello, Paolo ;
Diverio, Daniela ;
Roti, Giovanni ;
Tiacci, Enrico ;
Cazzaniça, Giovanni ;
Biondi, Andrea ;
Schnittger, Suzanne ;
Haferlach, Torsten ;
Hiddemann, Wolfgang ;
Martelli, Massimo F. ;
Gu, Wei ;
Mecucci, Cristina ;
Nicoletti, Ildo .
BLOOD, 2006, 107 (11) :4514-4523
[8]   Molecular origins of rapid and continuous morphological evolution [J].
Fondon, JW ;
Garner, HR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (52) :18058-18063
[9]   Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers [J].
Jeong, Eun Goo ;
Lee, Sung Hak ;
Yoo, Nam Jin ;
Lee, Sug Hyung .
APMIS, 2007, 115 (04) :341-346
[10]   NESbase version 1.0: a database of nuclear export signals [J].
la Cour, T ;
Gupta, R ;
Rapacki, K ;
Skriver, K ;
Poulsen, FM ;
Brunak, S .
NUCLEIC ACIDS RESEARCH, 2003, 31 (01) :393-396
12