The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models

被引：64

作者：

Leal, Sixto M., Jr. ^{[1
]}

Pearlman, Eric ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Ophthalmol & Visual Sci, Cleveland, OH 44106 USA

来源：

CYTOKINE | 2012年 / 58卷 / 01期

关键词：

Aspergillus; Fusarium; Keratitis; Toll-like Receptors; Dectin-1; FUSARIUM KERATITIS; CANDIDA-ALBICANS; INFECTIOUS KERATITIS; GENE-EXPRESSION; CORNEAL STROMA; CONTACT-LENSES; HUMAN DECTIN-1; HOST-DEFENSE; RISK-FACTORS; ASPERGILLUS;

D O I：

10.1016/j.cyto.2011.12.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fungal infections of the cornea are an important cause of blindness and visual impairment worldwide, with contact lens wear being the main risk factor in the USA and other industrialized countries, and traumatic injury being the main risk factor in developing countries. In this review, we highlight recent advances in the understanding of the host response to Aspergillus and Fusarium species in infected human corneal tissue and in mouse models of fungal keratitis. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：107 / 111

页数：5

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