The Crystal Structure and Cytotoxicity of Centrosymmetric Copper(II) Complex Derived from S-methyldithiocarbazate with Isatin

被引：24

作者：

Manan, Mohd Abdul Fatah Abdul ^{[1
]}

Tahir, M. Ibrahim M. ^{[2
]}

Crouse, Karen A. ^{[2
]}

Rosli, Rozita ^{[3
]}

How, Fiona N. -F. ^{[2
]}

Watkin, David J. ^{[4
]}

机构：

[1] Univ Teknol MARA, Fac Sci Appl, Shah Alam 40450, Selangor, Malaysia

[2] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia

[3] Univ Putra Malaysia, Dept Obstet & Gynaecol, Serdang 43400, Selangor, Malaysia

[4] Univ Oxford, Chem Chem Res Lab, Oxford OX1 3QA, England

来源：

JOURNAL OF CHEMICAL CRYSTALLOGRAPHY | 2011年 / 41卷 / 12期

关键词：

Copper(II); Centrosymmetric; Dithiocarbazate; MCF-7; Schiff base; X-RAY CRYSTAL; SCHIFF-BASES; SPECTROSCOPIC CHARACTERIZATION; PLATINUM(II) COMPLEXES; CADMIUM(II) COMPLEXES; BIOLOGICAL-ACTIVITY; ZINC(II); 2,6-DIACETYLPYRIDINE; BENZYLDITHIOCARBAZATE; DITHIOCARBAZATE;

D O I：

10.1007/s10870-011-0190-8

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human non-metastatic mammary gland adenocarcinoma cell line with an IC50 value 0.45 mu g/mL. The crystal structure of this centrosymmetric Cu(SMISA)(2) complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur.

引用

页码：1866 / 1871

页数：6

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