Role of IL-10 in allergen-specific immunotherapy and normal response to allergens

被引：36
作者：
Akdis, CA [1 ]
Blaser, K [1 ]
机构：
[1] Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland
来源：
MICROBES AND INFECTION | 2001年 / 3卷 / 11期
关键词：
interleukin-10; specific immunotherapy; tolerance; anergy; CD28;
D O I：
10.1016/S1286-4579(01)01449-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Induction of specific unresponsiveness (tolerance/anergy) in peripheral T cells by interleukin-10 (IL-10) and recovery by cytokines from the tissue microenvironment represent two key steps in specific immunotherapy of allergy and in natural exposure to allergens in healthy individuals. IL-10 elicits anergy in T cells by selective inhibition of the CD28 costimulatory pathway and controls suppression and development of antigen-specific immunity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：891 / 898
页数：8
相关论文
共 77 条
  • [51] Effects of peptide therapy on ex vivo T-cell responses
    Marcotte, GV
    Braun, CM
    Norman, PS
    Nicodemus, CF
    Kagey-Sobotka, A
    Lichtenstein, LM
    Essayan, DW
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 101 (04) : 506 - 513
  • [52] Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells
    Marshall, JS
    LealBerumen, I
    Nielsen, L
    Glibetic, M
    Jordana, M
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (04) : 1122 - 1128
  • [53] MOSMANN TR, 1996, IMMUNOL TODAY, V17, P142
  • [54] IMMUNOTHERAPY WITH HONEYBEE VENOM AND YELLOW JACKET VENOM IS DIFFERENT REGARDING EFFICACY AND SAFETY
    MULLER, U
    HELBLING, A
    BERCHTOLD, E
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (02) : 529 - 535
  • [55] Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
    Müller, U
    Akdis, CA
    Fricker, M
    Akdis, M
    Blesken, T
    Bettens, F
    Blaser, K
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 101 (06) : 747 - 754
  • [56] MULLER U, 1993, ALLERGY S14, V48, P36
  • [57] Treatment of cat allergy with T-cell reactive peptides
    Norman, PS
    Ohman, JL
    Long, AA
    Creticos, PS
    Gefter, MA
    Shaked, Z
    Wood, RA
    Eggleston, PA
    Hafner, KB
    Rao, P
    Lichtenstein, LM
    Jones, NH
    Nicodemus, CF
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 154 (06) : 1623 - 1628
  • [58] CD40 expression by human peripheral blood eosinophils
    Ohkawara, Y
    Lim, KG
    Xing, Z
    Glibetic, M
    Nakano, K
    Dolovich, J
    Croitoru, K
    Weller, PF
    Jordana, M
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (07) : 1761 - 1766
  • [59] LYMPHOCYTE-RESPONSES AND CYTOKINES
    PAUL, WE
    SEDER, RA
    [J]. CELL, 1994, 76 (02) : 241 - 251
  • [60] T-CELL ANTIGEN CD28 INTERACTS WITH THE LIPID KINASE PHOSPHATIDYLINOSITOL 3-KINASE BY A CYTOPLASMIC TYR(P)-MET-XAA-MET MOTIF
    PRASAD, KVS
    CAI, YC
    RAAB, M
    DUCKWORTH, B
    CANTLEY, L
    SHOELSON, SE
    RUDD, CE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) : 2834 - 2838
12345678