Role of IL-10 in allergen-specific immunotherapy and normal response to allergens

被引：36
作者：
Akdis, CA [1 ]
Blaser, K [1 ]
机构：
[1] Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland
来源：
MICROBES AND INFECTION | 2001年 / 3卷 / 11期
关键词：
interleukin-10; specific immunotherapy; tolerance; anergy; CD28;
D O I：
10.1016/S1286-4579(01)01449-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Induction of specific unresponsiveness (tolerance/anergy) in peripheral T cells by interleukin-10 (IL-10) and recovery by cytokines from the tissue microenvironment represent two key steps in specific immunotherapy of allergy and in natural exposure to allergens in healthy individuals. IL-10 elicits anergy in T cells by selective inhibition of the CD28 costimulatory pathway and controls suppression and development of antigen-specific immunity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：891 / 898
页数：8
相关论文
共 77 条
  • [1] Role of interleukin 10 in specific immunotherapy
    Akdis, CA
    Blesken, T
    Akdis, M
    Wüthrich, B
    Blaser, K
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (01) : 98 - 106
  • [2] Akdis CA, 1998, EUR J IMMUNOL, V28, P914, DOI 10.1002/(SICI)1521-4141(199803)28:03<914::AID-IMMU914>3.0.CO
  • [3] 2-C
  • [4] IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy
    Akdis, CA
    Blaser, K
    [J]. FASEB JOURNAL, 1999, 13 (06) : 603 - 609
  • [5] Epitope-specific T cell tolerance to phospholipase A(2) in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro
    Akdis, CA
    Akdis, M
    Blesken, T
    Wymann, D
    Alkan, SS
    Muller, U
    Blaser, K
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (07) : 1676 - 1683
  • [6] Akdis CA, 1997, STRATEGIES FOR IMMUNOINTERVENTIONS IN DERMATOLOGY, P131
  • [7] Glucocorticoids inhibit human antigen-specific and enhance total IgE and IgG4 production due to differential effects on T and B cells in vitro
    Akdis, CA
    Blesken, T
    Akdis, M
    Alkan, SS
    Heusser, CH
    Blaser, K
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (09) : 2351 - 2357
  • [8] Induction and differential regulation of bee venom phospholipase A(2)-specific human IgE and IgG(4) antibodies in vitro requires allergen-specific and nonspecific activation of T and B cells
    Akdis, CA
    Blesken, T
    Akdis, M
    Alkan, SS
    Wuthrich, B
    Heusser, CH
    Blaser, K
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 99 (03) : 345 - 353
  • [9] AKDIS CA, 2000, IN PRESS FASEB J
  • [10] BACETTA R, 1994, J EXP MED, V179, P493
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