Structural Basis of ß-Amyloid-Dependent Synaptic Dysfunctions

被引：56

作者：

Haupt, Christian ^{[2
,3
]}

Leppert, Joerg ^{[1
]}

Roenicke, Raik ^{[4
]}

Meinhardt, Jessica ^{[1
]}

Yadav, Jay K. ^{[2
,3
]}

Ramachandran, Ramadurai ^{[1
]}

Ohlenschlaeger, Oliver ^{[1
]}

Reymann, Klaus G. ^{[4
]}

Goerlach, Matthias ^{[1
]}

Faendrich, Marcus ^{[2
,3
]}

机构：

[1] Fritz Lipmann Inst, Leibniz Inst Age Res, D-07745 Jena, Germany

[2] Max Planck Res Unit Enzymol Prot Folding, D-06120 Halle, Germany

[3] MLU, D-06120 Halle, Germany

[4] DZNE Standort Magdeburg, Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 07期

关键词：

Alzheimer's disease; neurotoxicity; oligomers; solid-state structures; NMR spectroscopy; OLIGOMERS; MECHANISMS; DISEASE;

D O I：

10.1002/anie.201105638

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Learn about Alzheimer: The molecular conformation of a toxic β-amyloid oligomer structure was determined by NMR spectroscopy (see picture). The measurements show a N-terminal β strand that controls the partitioning between oligomer and protofibril formation. Targeting the N-terminus of the peptide neutralizes Aβ-dependent neuronal dysfunctions. The data have important implications for understanding the structural basis of Alzheimer's disease. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1576 / 1579

页数：4

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