Effectiveness of interventions for unstable patients on antiretroviral therapy in South Africa: results of a cluster-randomised evaluation

被引:19
作者
Fox, Matthew P. [1 ,2 ,3 ]
Pascoe, Sophie J. S. [2 ]
Huber, Amy N. [2 ]
Murphy, Joshua [2 ]
Phokojoe, Mokgadi [4 ]
Gorgens, Marelize [5 ]
Rosen, Sydney [1 ,2 ]
Wilson, David [5 ]
Pillay, Yogan [4 ]
Fraser-Hurt, Nicole [5 ]
机构
[1] Boston Univ, Sch Publ Hlth, Dept Global Hlth, Boston, MA 02215 USA
[2] Univ Witwatersrand, Sch Clin Med, Fac Hlth Sci, Hlth Econ & Epidemiol Res Off,Dept Internal Med, Johannesburg, South Africa
[3] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA
[4] Natl Dept Hlth, Pretoria, South Africa
[5] World Bank Grp, Washington, DC USA
关键词
adherence counseling; antiretroviral therapy; attrition; differentiated care; HIV; patient tracing; retention; SUB-SAHARAN AFRICA; HIV TREATMENT; FOLLOW-UP; CARE; PROGRAM; JOHANNESBURG; PREVENTION; INITIATION; RETENTION; MODELS;
D O I
10.1111/tmi.13152
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background As loss from HIV care is an ongoing challenge globally, interventions are needed for patients who don't achieve or maintain ART stability. The 2015 South African National Adherence Guidelines (AGL) for Chronic Diseases include two interventions targeted at unstable patients: early tracing of patients who miss visits (TRIC) and enhanced adherence counselling (EAC). Methods As part of a cluster-randomised evaluation at 12 intervention and 12 control clinics in four provinces, intervention sites implemented the AGL interventions, while control sites retained standard care. We report on outcomes of EAC for patients with an elevated viral load (>400 copies/ml) and for TRIC patients who missed a visit by >5 days. We estimated risk differences (RD) of 3 and 12-month viral resuppression (<400 copies/ml) and 12-month retention with cluster adjustment using generalised estimating equations and controlled for imbalances using difference-in-differences compared to all eligible in 2015, prior to intervention roll-out. Results For EAC, we had 358 intervention and 505 control site patients (61% female, median ART initiation CD4 count 154 cells/mu l). We found no difference between arms in 3-month resuppression (RD: -1.7%; 95%CI: -4.3% to 0.9%), but <20% of patients had a repeat viral load within 3 months (19.8% intervention, 13.5% control). Including the entire clinic population eligible for EAC with a repeat viral load at all evaluation sites (n = 934), intervention sites showed a small increase in 3-month resuppression (28% vs. 25%, RD 3.0%; 95%CI: -2.7% to 8.8%). Adjusting for baseline differences increased the RD to 8.1% (95% CI: -0.1% to 17.2%). However, we found no differences in 12-month suppression (RD: 1.5%; 95% CI: -14.1% to 17.1% but suppression was low overall at 40%) or retention (RD: 2.8%; 95% CI: -7.5% to 13.2%). For TRIC, we enrolled 155 at intervention sites and 248 at control sites (44% >40 years, 67% female, median CD4 count 212 cells/mu l). We found no difference between groups in return to care by 12 months (RD: -6.8%; 95% CI: -17.7% to 4.8%). During the study period, control sites continued to use tracing within standard care, however, potentially masking intervention effects. Conclusions Enhanced adherence counselling showed no benefit over 12 months. Implementation of the tracing intervention under the new guidelines was similar to the standard of care. Interventions that aim to return unstable patients to care should incorporate active monitoring to determine if the interventions are effective.
引用
收藏
页码:1314 / 1325
页数:12
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