Double filtration plasmapheresis: Determination of the optimal albumin concentration in the supplementation fluid

被引:14
作者
Mineshima, Michio [1 ]
机构
[1] Tokyo Womens Med Univ, Dept Clin Engn, Tokyo, Japan
关键词
Double filtration plasmapheresis; Continuous hematocrit monitoring; Variable blood volume model; Optimal albumin concentration of the supplementation fluid;
D O I
10.1016/j.transci.2017.08.009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Many kinds of technologies have been introduced and successfully developed for therapeutic apheresis. During the DFPP treatments, the patient's blood volume (By) often decreases with time due to albumin loss induced by inadequate albumin infusion in a supplementation fluid. We examined the change of BV by a continuous hematocrit (HCT) monitor, CRIT-LINE (TM), during an in vivo study for nine patients. As a result, albumin loss was fairly occurred in some DFPP treatments. The decrease of patient's BV was induced by an oncotic pressure drop due to albumin loss and often resulted in a blood pressure drop. This is a serious problem for DFPP. We should avoid the patient is suffering from these adverse effects. In order to determine the optimal concentration C-s and volume V-s values of a supplemented albumin solution, we introduced a variable blood volume model for albumin transport in DFPP. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:654 / 656
页数:3
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