Risk Factors for Medication Non-Adherence in an HIV Infected Population in the Dominican Republic

被引：32

作者：

Harris, Julian ^{[2
]}

Pillinger, Mara ^{[3
]}

Fromstein, Deborah ^{[4
]}

Gomez, Bayardo ^{[5
]}

Garris, Ivelisse ^{[6
]}

Kanetsky, Peter A. ^{[1
]}

Tebas, Pablo ^{[7
,8
]}

Gross, Robert ^{[1
,7
,8
]}

机构：

[1] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

[2] Harvard Univ, Brigham & Womens Hosp, Dept Med Resident, Sch Med, Boston, MA 02115 USA

[3] Univ Penn, Sch Arts & Sci, Philadelphia, PA 19104 USA

[4] Univ Washington, Dept Med Resident, Washington, DC USA

[5] Hlth Promot & Human Solidar Ctr CEPROSH, Puerto Plata, Dominican Rep

[6] Galvan Hlth Ctr, Santo Domingo, Dominican Rep

[7] Univ Penn, Sch Med, Dept Med Infect Dis, Philadelphia, PA 19104 USA

[8] Univ Penn, Ctr AIDS Res CFAR, Philadelphia, PA 19104 USA

来源：

AIDS AND BEHAVIOR | 2011年 / 15卷 / 07期

关键词：

HIV-1; Antiretroviral therapy; Adherence; Developing world; ACTIVE ANTIRETROVIRAL THERAPY; RANDOMIZED CONTROLLED-TRIAL; RESOURCE-LIMITED SETTINGS; SOUTH-AFRICAN ADULTS; VIRAL LOAD; DRUG-USERS; ADHERENCE; SURVIVAL; ALCOHOL; METAANALYSIS;

D O I：

10.1007/s10461-010-9781-1

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

High levels of medication adherence are central to HIV treatment success. Barriers to medication adherence may differ by cultural setting. We aimed to determine risk factors for medication non-adherence in HIV infected individuals in the Dominican Republic. Adherence was measured in 300 individuals using a visual analog scale assessing the prior month and dichotomized at 95%. High levels of adherence were reported by 228 (76%). Risk factors for non-adherence included heavy alcohol use: 2.5 times odds (95% CI: 1.4-4.5), having children: 2.2 times higher odds (95% CI: 1.1-4.9) and perceptions of less social support related to adherence: 2 times higher odds (95% CI: 1.1-3.6). Culturally appropriate interventions are needed to address alcohol use, which is common in this setting. Parenting may represent a competing demand on time and resources and be an adherence barrier. Self-reported perceived lack of adherence support may be a useful marker for need for adherence interventions.

引用

页码：1410 / 1415

页数：6

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