Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: Role in Ca2+ signaling and disease

被引：67

作者：

Distelhorst, Clark W. ^{[1
,2
,4
]}

Bootman, Martin D. ^{[3
]}

机构：

[1] Case Western Reserve Univ, Dept Med, Div Hematol Oncol, Case Comprehens Canc Ctr,Sch Med, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Hematol Oncol, Case Comprehens Canc Ctr, Sch Med, Cleveland, OH 44106 USA

[3] Babraham Inst, Mol Signalling Lab, Cambridge CB22 3AT, England

[4] Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Dept Pharmacol, Cleveland, OH 44106 USA

来源：

CELL CALCIUM | 2011年 / 50卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Calcium; Inositol 1,4,5-trisphosphate receptor; Bcl-2; Bcl-xl; Apoptosis; Chronic lymphocytic leukemia; Bipolar disorder; ENDOPLASMIC-RETICULUM; INTRACELLULAR CALCIUM; CELL-DEATH; MITOCHONDRIAL CA2+; TRISPHOSPHATE RECEPTOR; IP3; RECEPTORS; APOPTOSIS; RELEASE; BAX; ER;

D O I：

10.1016/j.ceca.2011.05.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channel to regulate IP3-mediated Ca2+ release from the endoplasmic reticulum. This review summarizes the current state of knowledge regarding the interaction of Bcl-2, and also its homologue Bcl-xl, with the IP3R and how these interactions regulate Ca2+ signaling. The dual role of these interactions in promoting prosurvival Ca2+ signals, while at the same time inhibiting proapoptotic Ca2+ signals, is discussed. Moreover, this review will elucidate the recently recognized importance of the Bcl-2-IP3R interaction in human disease. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：234 / 241

页数：8

共 96 条

[1] High level calcineurin activity predisposes neuronal cells to apoptosis [J].

Asai, A ;

Qiu, JH ;

Narita, Y ;

Chi, S ;

Saito, N ;

Shinoura, N ;

Hamada, H ;

Kuchino, Y ;

Kirino, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (48) :34450-34458

[2]

BAFFY G, 1993, J BIOL CHEM, V268, P6511

[3] CLONING THE CHROMOSOMAL BREAKPOINT OF T(14-18) HUMAN LYMPHOMAS - CLUSTERING AROUND JH ON CHROMOSOME-14 AND NEAR A TRANSCRIPTIONAL UNIT ON 18 [J].

BAKHSHI, A ;

JENSEN, JP ;

GOLDMAN, P ;

WRIGHT, JJ ;

MCBRIDE, OW ;

EPSTEIN, AL ;

KORSMEYER, SJ .

CELL, 1985, 41 (03) :899-906

[4] Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis [J].

Bassik, MC ;

Scorrano, L ;

Oakes, SA ;

Pozzan, T ;

Korsmeyer, SJ .

EMBO JOURNAL, 2004, 23 (05) :1207-1216

[5] Calcium signalling: Dynamics, homeostasis and remodelling [J].

Berridge, MJ ;

Bootman, MD ;

Roderick, HL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) :517-529

[6] The versatility and universality of calcium signalling [J].

Berridge, MJ ;

Lipp, P ;

Bootman, MD .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (01) :11-21

[7] Calcium - a life and death signal [J].

Berridge, MJ ;

Bootman, MD ;

Lipp, P .

NATURE, 1998, 395 (6703) :645-648

[8] The AM and FM of calcium signalling [J].

Berridge, MJ .

NATURE, 1997, 386 (6627) :759-760

[9] The inositol 1,4,5-trisphosphate receptors [J].

Bezprozvanny, I .

CELL CALCIUM, 2005, 38 (3-4) :261-272

[10] Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes [J].

Calin, George A. ;

Croce, Carlo M. .

BLOOD, 2009, 114 (23) :4761-4770

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