Polymorphisms of the ABCB1 Gene in the Pakistani Population

被引:0
作者
Farhat, Kulsoom [1 ]
Waheed, Akbar [1 ]
Hussain, Azhar [2 ]
Iqbal, Javeid [3 ]
Mansoor, Qaisar [4 ]
Ismail, Muhammad [4 ]
机构
[1] Army Med Coll, Dept Pharmacol & Therapeut, Rawalpindi, Pakistan
[2] Hamdard Inst Pharmaceut Sci, Dept Pharm, Islamabad, Pakistan
[3] Univ Baluchistan, Dept Pharm, Quetta, Pakistan
[4] Inst Biomed & Genet Engn, Dept Genet, Islamabad, Pakistan
来源
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN | 2015年 / 25卷 / 07期
关键词
P-glycoprotein; Polymorphism; ABCB1; Genotyping; Pakistan; MDR1; GENE; P-GLYCOPROTEIN; TRANSPORTERS; FREQUENCY; C3435T; PHARMACOKINETICS; DISPOSITION; GENOTYPE; CANCER; ALLELE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To investigate the frequency of the single nucleotide polymorphism C1236T in exon 12 of the ABCB1 gene in Pakistani population and to compare it with published data on Asian and Caucasian populations. Study Design: A cross-sectional observational study. Place and Duration of Study: Combined Military Hospital, Rawalpindi and Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, from August 2012 to May 2013. Methodology: C1236T polymorphism was investigated in 426 Pakistani subjects. The frequency was compared with the published data on other Asian and Caucasian populations. Results: The frequencies of ABCB1 C1236T were 16.4% for CC, 44.1% for CT and 39.4% for TT. Pakistanis differed significantly from all the European populations compared in the distribution of the TT genotype of C1236T ABCB1 (p < 0.05). The Pakistani population also differed significantly from some of the European populations in the distribution of CC and CT genotype (p < 0.05). Conclusion: There was significant difference in the genotype frequency of the ABCB1 gene compared to other populations. This study has provided a framework for future pharmacogenetic and pharmacokinetic studies on this polymorphic variant of ABCB1 gene in the Pakistani population.
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收藏
页码:482 / 485
页数:4
相关论文
共 25 条
  • [1] MDR1 gene polymorphisms are associated with neuropsychiatric adverse effects of mefloquine
    Aarnoudse, Albert L. H. J.
    van Schaik, Ron H. N.
    Dieleman, Jeanne
    Molokhia, Mariam
    van Riemsdijk, Melanie M.
    Ligthelm, Robert J.
    Overbosch, David
    van der Heiden, Ilse P.
    Stricker, Bruno H. Ch.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2006, 80 (04) : 367 - 374
  • [2] Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
    Aller, Stephen G.
    Yu, Jodie
    Ward, Andrew
    Weng, Yue
    Chittaboina, Srinivas
    Zhuo, Rupeng
    Harrell, Patina M.
    Trinh, Yenphuong T.
    Zhang, Qinghai
    Urbatsch, Ina L.
    Chang, Geoffrey
    [J]. SCIENCE, 2009, 323 (5922) : 1718 - 1722
  • [3] [Anonymous], 1989, Cold Spring Harbor
  • [4] Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel
    Bosch, Tessa M.
    Huitema, Alwin D. R.
    Doodeman, Valerie D.
    Jansen, Robert
    Witteveen, Els
    Smit, Wim M.
    Jansen, Rob L.
    van Herpen, Carla M.
    Soesan, Marcel
    Beijnen, Jos H.
    Schellens, Jan H. M.
    [J]. CLINICAL CANCER RESEARCH, 2006, 12 (19) : 5786 - 5793
  • [5] Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
    Cascorbi, I
    Gerloff, T
    Johne, A
    Meisel, C
    Hoffmeyer, S
    Schwab, M
    Schaeffeler, E
    Eichelbaum, M
    Brinkmann, U
    Roots, I
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) : 169 - 174
  • [6] Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients
    Chowbay, B
    Cumaraswamy, S
    Cheung, YB
    Zhou, QY
    Lee, EJD
    [J]. PHARMACOGENETICS, 2003, 13 (02): : 89 - 95
  • [7] ABC transporters in cancer: more than just drug efflux pumps
    Fletcher, Jamie I.
    Haber, Michelle
    Henderson, Michelle J.
    Norris, Murray D.
    [J]. NATURE REVIEWS CANCER, 2010, 10 (02) : 147 - 156
  • [8] Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population
    Gaikovitch, EA
    Cascorbi, I
    Mrozikiewicz, PM
    Brockmöller, J
    Frötschl, R
    Köpke, K
    Gerloff, T
    Chernov, JN
    Roots, I
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 59 (04) : 303 - 312
  • [9] Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population
    Gumus-Akay, G.
    Rustemoglu, A.
    Karadag, A.
    Sunguroglu, A.
    [J]. GENETICS AND MOLECULAR RESEARCH, 2008, 7 (04) : 1193 - 1199
  • [10] Jabir RS, 2012, PHARMACOGENOMICS, V13, P1979, DOI [10.2217/pgs.12.165, 10.2217/PGS.12.165]