The foundations and development of lipidomics

被引:143
作者
Han, Xianlin [1 ,2 ,3 ]
Gross, Richard W. [4 ,5 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA
[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Diabet, San Antonio, TX 78229 USA
[4] Washington Univ, Div Bioorgan Chem & Mol Pharmacol, Dept Internal Med, Sch Med, St Louis, MO USA
[5] Washington Univ, Dept Chem, St Louis, MO USA
关键词
lipids; lipid metabolism; mass spectrometry; soft ionization; electrospray ionization; matrix-assisted laser desorption; ionization; shotgun lipidomics; chromatographic separation; charge-switch derivatization; TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; ASSISTED LASER-DESORPTION; COLLISIONALLY ACTIVATED DISSOCIATION; MOLECULAR-SPECIES COMPOSITION; ELECTROSPRAY-IONIZATION; SHOTGUN LIPIDOMICS; QUANTITATIVE-ANALYSIS; OXIDATIVE LIPIDOMICS; MULTIPLE PRECURSOR;
D O I
10.1016/j.jlr.2021.100164
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
For over a century, the importance of lipid metabolism in biology was recognized but difficult to mechanistically understand due to the lack of sensitive and robust technologies for identification and quantification of lipid molecular species. The enabling technological breakthroughs emerged in the 1980s with the development of soft ionization methods (Electrospray Ionization and Matrix Assisted Laser Desorption/Ionization) that could identify and quantify intact individual lipid molecular species. These soft ionization technologies laid the foundations for what was to be later named the field of lipidomics. Further innovative advances in multistage fragmentation, dramatic improvements in resolution and mass accuracy, and multiplexed sample analysis fueled the early growth of lipidomics through the early 1990s. The field exponentially grew through the use of a variety of strategic approaches, which included direct infusion, chromatographic separation, and charge-switch derivatization, which facilitated access to the low abundance species of the lipidome. In this Thematic Review, we provide a broad perspective of the foundations, enabling advances, and predicted future directions of growth of the lipidomics field.
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页数:15
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