Novel Structural Hybrids of Pyrrole and Thiazole Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities

被引：13

作者：

Salem, Mohamed A. ^{[1
]}

Abbas, Samir Y. ^{[2
]}

El-Sharief, Marwa A. M. ^{[1
,3
]}

Helal, Mohamed H. ^{[4
]}

Gouda, Moustafa A. ^{[5
]}

Assiri, Mohammed A. ^{[6
]}

Ali, Tarik E. ^{[6
,7
]}

机构：

[1] King Khalid Univ, Fac Sci & Arts, Dept Chem, Mohail, Assir, Saudi Arabia

[2] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Cairo, Egypt

[3] Natl Res Ctr, Appl Organ Chem Dept, Cairo, Egypt

[4] Northern Border Univ, Fac Arts & Sci, Dept Chem, Rafha, Saudi Arabia

[5] Taibah Univ, Fac Sci & Arts, Dept Chem, Medina, Saudi Arabia

[6] King Khalid Univ, Fac Sci, Dept Chem, Abha, Saudi Arabia

[7] Ain Shams Univ, Fac Educ, Dept Chem, Cairo, Egypt

来源：

ACTA CHIMICA SLOVENICA | 2021年 / 68卷 / 04期

关键词：

Pyrroles; Thiosemicarbazones; Thiazoles; Antibacterial activity; Antifungal activity; BIOLOGICAL EVALUATION; HIGHLY POTENT; DERIVATIVES; INHIBITORS; DESIGN; SERIES; AGENTS;

D O I：

10.17344/acsi.2021.6980

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One of the best ways to design new biocidal agents is synthesizing hybrid molecules by combining two or more bioactive moieties in a single molecular scaffold. So, new series of pyrroles bearing a thiazole moiety were synthesized using 1-methyl-1H-pyrrole-2-carbaldehyde thiosemicarbazones 1a-c. Cyclization of thiosemicarbazone derivatives 1a-c with ethyl chloroacetate, ethyl 2-chloropropanoate, chloroacetone and phenacyl bromide afforded the corresponding thiazolidin-4-ones 2a-c, 5-methylthiazolidin-4-ones 3a-c, 4-methyl-2,3-dihydrothiazoles 4a-c, and 4-phenyl-2,3-dihydrothiazoles 5a-c, respectively. The antimicrobial activity of the new thiazole derivatives was evaluated.

引用

页码：990 / 996

页数：7

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