Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds?

被引：111

作者：

Sharma, Bharvi ^{[1
]}

Kumar, Vipan ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 64卷 / 23期

关键词：

VITRO ANTIMALARIAL ACTIVITY; ESTROGEN-RECEPTOR MODULATORS; IN-VITRO; BIOLOGICAL EVALUATION; PLASMODIUM-FALCIPARUM; DERIVATIVES SYNTHESIS; ANTIPROLIFERATIVE ACTIVITIES; CONJUGATES SYNTHESIS; ANTICANCER ACTIVITY; CYTOTOXIC ACTIVITY;

D O I：

10.1021/acs.jmedchem.1c00390

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ferrocene is an important structural core in bioorganometallic chemistry because of its inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are two of the most notable contributions of ferrocene to medicinal chemistry with remarkable antimalarial and anticancer properties. The improved medicinal properties of these drug candidates highlight the impact that ferrocene can have on the molecular and biological properties of the bioactive compounds. In this Perspective, we investigate the scope and limitations of ferrocene incorporation into organic compounds/natural products on their mode of action and biological activities. We have also discussed the detailed role of ferrocene modifications in influencing the anticancer, antimalarial, and antimicrobial properties of various bioactive moieties to design safer and promising ferrocene-based drugs.

引用

页码：16865 / 16921

页数：57

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